Treatment of oral premaligant hyperkeratotic lesions with topical calcipotriol versus tretinoin & its suppressive effect on salivary MMP-9 level : A randomized clinical trial / Rania Hassan Shalaby ; Supervised Khaled Elgaaly , Dalia Ghalwash , Olfat Shaker

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Rania Hassan Shalaby

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Material type: Text

TextLanguage: English Publication details: Cairo : Rania Hassan Shalaby , 2016Description: 178 P. : charts , facsimiles , Photographs ; 25cmOther title:

MMP-9 علاج افات ما قبل السرطان الفموي عن طريق الكالسيبوتريول الموضعي بالمقارنه بالتريتينوين الموضعي و اختبار تاثيرهم في تثبيط مستوي ال : تجربه طبيه عشوائه [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology Summary: Objective: The primary objective of this study was to compare the effectiveness of topical calcipotriol versus topical tretinoin in treatment of oral leukoaplakia and oral lichen planus regarding clinical improvement as well as their suppressive effect on salivary MMP-9 level which is considered a prognostic marker for malignant transformation. Materials & Methods: Clinical scores were measured at 0,2 and 4 weeks of treatment with 50 mcg/g calcipotriol in an adhesive vehicle and 0.5% Tretinoin cream applied twice daily for 4 weeks. Also, saliva was collected before and after treatment to compare salivary MMP-9 level using ELIZA kit. Results: Results showed that topical calcipotriol is as effective as topical tretinoin in the clinical improvement of oral hyperkeratotic potentially malignant lesions. Both topical tretinoin and calcipotriol resulted in suppression of salivary MMP-9 level. Therefore, they may have role in monitoring the progress of potentially malignant lesions into carcinoma

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.09.08.Ph.D.2016.Ra.T (Browse shelf(Opens below))		Not for loan	01010110072708000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.09.08.Ph.D.2016.Ra.T (Browse shelf(Opens below))	72708.CD	Not for loan	01020110072708000

Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

Objective: The primary objective of this study was to compare the effectiveness of topical calcipotriol versus topical tretinoin in treatment of oral leukoaplakia and oral lichen planus regarding clinical improvement as well as their suppressive effect on salivary MMP-9 level which is considered a prognostic marker for malignant transformation. Materials & Methods: Clinical scores were measured at 0,2 and 4 weeks of treatment with 50 mcg/g calcipotriol in an adhesive vehicle and 0.5% Tretinoin cream applied twice daily for 4 weeks. Also, saliva was collected before and after treatment to compare salivary MMP-9 level using ELIZA kit. Results: Results showed that topical calcipotriol is as effective as topical tretinoin in the clinical improvement of oral hyperkeratotic potentially malignant lesions. Both topical tretinoin and calcipotriol resulted in suppression of salivary MMP-9 level. Therefore, they may have role in monitoring the progress of potentially malignant lesions into carcinoma

Issued also as CD

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