Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background : contionus glucose moniyoring highlights the complexity of postprandial glucode and points to the limitations of current appoach based on arbohydrate counting. Objective: To determine the effect protein and fat on post prandial glycemia in patients with type 1 diabetes. Research design and methods: Prospective study-follow up. This study included 51 children and adolescents with type 1 diabetes following up at Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU), Abo Elrish Children hospital, Cairo University. We compared post prandial blood glucose levels following three breakfast meals with varying protein and fat content (standard carbohydrate meal, high fat meal, high protein meal) over a period of 5 hours on 3 consecutive days. Results: High protein meal caused hyperglycemia with a peak at 3-4 hours and continues for 5 hours while high fat meal caused early hyperglycemia reached a peak at 2 hours then declined towards 5 hours. Comparing the three different meals there was a significant p value {u2264} 0.05 regarding postprandial glycemia at 30, 60, 90,120, 180, 210, 240, 270, 300 minutes after breakfast meal. Conclusion: Meals high in protein and fat increase glucose excursions postprandial over a period of 5 hours

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