Thesis (Ph.D.) - Cairo University - National Institute of Enhanced Laser Sciences - Department of Laser Applications in Medical and Biological

Psoriasis is a commonly encountered chronic dermatological disease, presenting with inflammatory symptoms in patients. Systemic treatment of psoriasis is associated with several adverse effects; therefore the development of a customized topical treatment modality for psoriasis would be an interesting alternative to systemic delivery. The therapeutic modality explored in this study was the comparative treatment of psoriatic patients using nanoparticulated methotrexate in the form of jojoba oil based microemulsion with or without fractional erbium YAG laser. Assessment parameters included follow up photography for up to 8 weeks of treatment, estimation of the psoriasis severity score of the treated lesions which is the score of thickness, erythema, scales (TES score), and histopathological skin evaluation. Results revealed that the prepared methotrexate microemulsion was clinically beneficial and safe in treatment of psoriasis vulgaris. The concomitant use of the fractional laser provided improvement in the psoriatic plaques within shorter time duration (3 weeks compared to 8 weeks of treatment), presenting an alternative topical treatment modality for psoriasis vulgaris

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