Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Ophthalmology

Purpose: To identify Optical coherence tomography (OCT) biomarkers for visual outcome after injection of intraviteal bevacizumab in the treatment of diabetic macular edema (DME). Materials and Methods: Prospective observational study conducted on eyes with DME with central subfield thickness (CST) more than 250 microns. OCT & best corrected visual acuity (BCVA) were done then eyes received three intravitreal injections of bevacizumab then the BCVA and OCT were repeated after one month of the third injection. Results: We found an improvement both functionally and anatomically. Functionally; the pattern of edema especially combined and subretinal fluid can be used as a biomarker for improvement of vision. Anatomically; subretinal fluid can be used as a biomarker for decrease of CST. Conclusions: The pattern of edema could be used as a reliable biomarker for the visual outcome in eyes with DME and the subretinal fluid is another biomarker that could be used to predict both the functional response as well as anatomical improvement of DME after the bevacizumab therapy

Issued also as CD