Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine

Background: Increased time on mechanical ventilation is associated with higher mortality rates. Weaning predictors were studied in an attempt to evaluate the outcome of removing ventilatory support .weaning predictors were studied in an attempt to evaluate the outcome of removing ventilatory support. The Aim of present study was to evaluate role of the following parameters. NT-proBNP, weaning indices (RSBI, Cst and IWI) and echocardiography with use of tissue Doppler imaging (left and right ventricular function was assessed by LVEF, grade of mitral regurge if any, E/A, DT, E{u2019}, E/E{u2019}, TAPSE and RVFAC) as predictor tools of weaning failure in critically ill patients from mechanical ventilation. Patients who failed SBT showed (before SBT),: significantly longer MV duration , significant decrease in PaO2, SaO2 and PaO2/FiO2, and significant increase in RSBI ,significant decrease in IWI and significant decrease in Cst. Results: Patients who failed SBT showed (After SBT),: Significant increase in MAP, pulse and RR, Significant increase in NT-proBNP levels, significant increase CO , no difference incidence of systolic dysfunction

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