Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology

Background: Colorectal cancer is the third most common type of cancer and the fourth leading cause of cancer-related deaths worldwide. Ezrin is involved in maintaining cell structure and cell motility. Expression levels of the ezrin gene correlate with numerous human malignancies. Aim of this work: to determine the significance of ezrin in the development and progression of colorectal carcinoma to provide the evidence for clinical prognosis and suitable adjuvant therapy. Material & Methods: Ezrin expression was evaluated in fifty one cases of colorectal carcinoma by using two methods; objective and quantitative method to determine the statistical relation between ezrin objective analysis score and clinicopathological parameters and to do a comparative study between both methods of analysis. Results: Ezrin was expressed in 92.2% of cases, and it showed a statistical significant relation with tumor grade.There was no statistical relationship between ezrin expression and different clinicopathological findings. A statistically significant relation was found between ezrin objective analysis score and ezrin quantitative analysis score (P-value <0.05). A strong positive Pearson correlation exists between both methods of analysis (R=0.868)

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