Synthesis and application of molecularly imprinted polymers for the antiviral drug sofosbuvir / Muhammed Abdelhamied Abdeltawab Abdelhamied ; Supervised Rasha Mohamed Elnashar , Muhammad Gamal Abdelmoghny

بواسطة:

Muhammed Abdelhamied Abdeltawab Abdelhamied

المساهم:

نوع المادة :

نصاللغة: الإنجليزية تفاصيل النشر: Cairo : Muhammed Abdelhamied Abdeltawab Abdelhamied , 2020الوصف: 123 P . : charts , facsmilies ; 25cmعنوان آخر:

تحضير وتطبيق بوليمرات جزيئية الطباعة لعقار سوفوسبوفير المضاد للفيروسات [عنوان مضاف عنوان الصفحة]

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Issued also as CD

ملاحظة الأطروحة: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry ملخص: In this work, a biomimetic electrochemical sensor for sofosbuvir (SOFO) was designed and optimized for its determination in pure forms,pharmaceutical formulations, urine besides forced degradation products. Computational calculations, based on density functional theory (DFT) at the B3LYP/6-31G(d) level, were initially employed to screen some of the commonly used electropolymerizable functional monomers including para-aminothiophenol(PTP),ortho-aminophenol (OAP), ortho-phenylenediamine(OPD),and pyrrole (PY). Based on the computational calculations,the imprinted sensor active sites were engineered via electropolymerization of OAP, which was found to show the highest binding efficiency to the target drug, on a glassy carbon electrode(GCE)modified with functionalized multi-walled carbon nanotubes(f-MWCNTs)and reduced graphene oxide (RGO) nanocomposite for sensitive determination of SOFO

وسوم من هذه المكتبة: لا توجد وسوم لهذا العنوان في هذه المكتبة. قم بتسجيل الدخول لإضافة الوسوم.

المقتنيات
نوع المادة	المكتبة الحالية	المكتبة الرئيسية	رقم الاستدعاء	رقم النسخة	حالة	الباركود
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.08.M.Sc.2020.Mu.S (استعراض الرف(يفتح أدناه))		لا تعار	01010110082087000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.08.M.Sc.2020.Mu.S (استعراض الرف(يفتح أدناه))	82087.CD	لا تعار	01020110082087000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry

In this work, a biomimetic electrochemical sensor for sofosbuvir (SOFO) was designed and optimized for its determination in pure forms,pharmaceutical formulations, urine besides forced degradation products. Computational calculations, based on density functional theory (DFT) at the B3LYP/6-31G(d) level, were initially employed to screen some of the commonly used electropolymerizable functional monomers including para-aminothiophenol(PTP),ortho-aminophenol (OAP), ortho-phenylenediamine(OPD),and pyrrole (PY). Based on the computational calculations,the imprinted sensor active sites were engineered via electropolymerization of OAP, which was found to show the highest binding efficiency to the target drug, on a glassy carbon electrode(GCE)modified with functionalized multi-walled carbon nanotubes(f-MWCNTs)and reduced graphene oxide (RGO) nanocomposite for sensitive determination of SOFO

Issued also as CD

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Synthesis and application of molecularly imprinted polymers for the antiviral drug sofosbuvir / Muhammed Abdelhamied Abdeltawab Abdelhamied ; Supervised Rasha Mohamed Elnashar , Muhammad Gamal Abdelmoghny