Synthesis of Some Fused Pyrazine and Diazepine Derivatives of Biological Interest /
Mohamed Kamal Abd El hamid
Synthesis of Some Fused Pyrazine and Diazepine Derivatives of Biological Interest / تحضير بعض مشتقات البيرازين والدايازابين الملتحمة ذات الاهمية البيولوجية Mohamed Kamal Abd El hamid ; Supervised Mohga Mohamed Badran , SamihaMohamed Ali Roshdy - Cairo : Nour Shafik Elgendy , 2005 - 137P : charts ; 30cm
Thesis (PH.D.) - Cairo University - Faculty Of Pharmacy - Department Of Organic Chemistry
A survey covering the main general methods used for the synthesis of pyrroloquinoxaline , pyrrolothienopyrazine and pyrrolothienodiazepine derivatives is presented A brief outline of basic pharmacology of serotonin (5 - hydroxytryptamine , 5 - HT) and also the medicinal importance of some fused pyrazine and diazepine is given The different methods of preparing the starting compounds , intermediates and the final compounds are thoroughly investigated Open field test was done to determine changes of animal behaviors and as screening for antipsychotic activity , thus it can be concluded that some of the test compounds showed central sedative effects and possible anti - anxiety activity
antipsychotic activity pyrrolothienodiazepine pyrrolothienopyrazine sertonin
Synthesis of Some Fused Pyrazine and Diazepine Derivatives of Biological Interest / تحضير بعض مشتقات البيرازين والدايازابين الملتحمة ذات الاهمية البيولوجية Mohamed Kamal Abd El hamid ; Supervised Mohga Mohamed Badran , SamihaMohamed Ali Roshdy - Cairo : Nour Shafik Elgendy , 2005 - 137P : charts ; 30cm
Thesis (PH.D.) - Cairo University - Faculty Of Pharmacy - Department Of Organic Chemistry
A survey covering the main general methods used for the synthesis of pyrroloquinoxaline , pyrrolothienopyrazine and pyrrolothienodiazepine derivatives is presented A brief outline of basic pharmacology of serotonin (5 - hydroxytryptamine , 5 - HT) and also the medicinal importance of some fused pyrazine and diazepine is given The different methods of preparing the starting compounds , intermediates and the final compounds are thoroughly investigated Open field test was done to determine changes of animal behaviors and as screening for antipsychotic activity , thus it can be concluded that some of the test compounds showed central sedative effects and possible anti - anxiety activity
antipsychotic activity pyrrolothienodiazepine pyrrolothienopyrazine sertonin