Design synthesis and biological evaluation of novel B- Carboline derivatives as anticancer agents and phosphodiesterase inhibitors /

Mohammad Abdelhalim Abdelnaby

Design synthesis and biological evaluation of novel B- Carboline derivatives as anticancer agents and phosphodiesterase inhibitors / تصميم وتشييد وتقييم بيولوجى لبعض مشتقات البيتاكاربولين كمضادات للسرطان ومثبطات لانزيم فوسفودايستراز Mohammad Abdelhalim Abdelnaby ; Supervised Ashraf H. Abadi - Cairo : Mohammad Abdelhalim Abdelnaby , 2008 - 112Leaves : charts ; 30cm

Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Tadalafil is B -carboline derivative that has been introduced to the market as a medication for the treatment of the MED . Its mechanism of action involves inhibition of PDE5 , Leading to elevation of cGMP , Vascular relaxation in the corpora cavernosa and penile erection during sexual stimulation
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