Potentiometric determination of sibutramine using batch and flow injection analysis /

Nesrine Abdelrehim Elgohary

Potentiometric determination of sibutramine using batch and flow injection analysis / Nesrine Abdelrehim Elgohary ; Supervised Rasha Elnashar - Cairo : Nesrine Abdelrehim Elgohary , 2009 - 140 Leaves : charts ; 30cm

Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Analytical Chemistry

Sibutramine a synthetic compound for the treatmentof obesity is a centrally acting serotonin - norepinephrine reuptake inhibitor structurally related to amphetamines . The present work offers an ion - selective electrode of the plastic membrane type for the determination of sibutramine hydrochloride monohydrate (SBT) . The electrode depends mainly on the incorporation of the ion - associate of the above mentioned drug with phosphtungestic acid (PTA) in a PVC matrix
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