Exploring the effect of conformational variability on the biophysical identity of HCV NS5B polymerase /
Abdo Abdo Abdellah Mohamed Elfiky
Exploring the effect of conformational variability on the biophysical identity of HCV NS5B polymerase / إستكشاف تأثير التغير البنائى على الشخصية البيوفيزيائية لبوليماريز فيروس سى الكبدى الوبائى Abdo Abdo Abdellah Mohamed Elfiky ; Supervised Wael M. Elshemey , Wissam A. Gawad , Omar S. Desoky - Cairo : Abdo Abdo Abdellah Mohamed Elfiky , 2013 - 153 Leaves : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics
PS-7977, IDX-84 and R728 are hepatitis C virus (HCV) non-structural 5b (NS5B) RNA dependent RNA polymerase (RdRp) nucleotide inhibitors (NIs) that are currently in phase (DX-84 and R7128) and (PS-7977) clinical trials. The activated form of these Direct Acting aAntiviral (DAA) drugs acts on NS5B RdRp through a coordination bond with the two Mg+² present at the active site of the polymerase
HCV Molecular NS5B
Exploring the effect of conformational variability on the biophysical identity of HCV NS5B polymerase / إستكشاف تأثير التغير البنائى على الشخصية البيوفيزيائية لبوليماريز فيروس سى الكبدى الوبائى Abdo Abdo Abdellah Mohamed Elfiky ; Supervised Wael M. Elshemey , Wissam A. Gawad , Omar S. Desoky - Cairo : Abdo Abdo Abdellah Mohamed Elfiky , 2013 - 153 Leaves : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics
PS-7977, IDX-84 and R728 are hepatitis C virus (HCV) non-structural 5b (NS5B) RNA dependent RNA polymerase (RdRp) nucleotide inhibitors (NIs) that are currently in phase (DX-84 and R7128) and (PS-7977) clinical trials. The activated form of these Direct Acting aAntiviral (DAA) drugs acts on NS5B RdRp through a coordination bond with the two Mg+² present at the active site of the polymerase
HCV Molecular NS5B