Synthesis and pharmacological evaluation of novel monovalent and bivalent ligands for monomeric and dimeric melatonin receptors /

Mina Nabil Farid Morcos

Synthesis and pharmacological evaluation of novel monovalent and bivalent ligands for monomeric and dimeric melatonin receptors / Mina Nabil Farid Morcos ; Supervised Darius P. Zlotos - Cairo : Mina Nabil Farid Morcos , 2013 - 163 Leaves ; 30cm

Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Melatonin, the neurohormone secreted from the pineal gland, is responsible for the regulation of several physiological processes through interaction with two GPCRs, MT, and MT₂. The exact physiological role these two receptors is still unclear, and requires subtype selective melatonin ligands as pharmacological tools Recently a series of benzyloxy - substituted N-[3-(3-methoxyphenyl)propy) amides, exemplified by compound 24d
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