Novel melatonergic ligands with potential MT₁⁻ selectivity : Synthesis and pharmacological evaluation /
Noura Mohamed Salah Eldin Riad
Novel melatonergic ligands with potential MT₁⁻ selectivity : Synthesis and pharmacological evaluation / Noura Mohamed Salah Eldin Riad ; Supervised Darius P. Zlotos - Cairo : Noura Mohamed Salah Eldin Riad , 2013 - 140 Leaves ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Numerous functions of the neurohormone melatonin are mediated through activation of the G - protein - coupled receptors MT₁⁻ and MT₂. Elucidation of the pathophysiological function of the MT₁ receptor has been hampered mainly by the limited availability of selective full agonist and full antagonist for this receptor subtype. Design and synthesis of selective MT₁ receptor ligands with higher affinity and selectivity may contribute to better understanding of physiological functions mediated by MT₁ receptors
Novel melatonergic ligands with potential MT₁⁻ selectivity : Synthesis and pharmacological evaluation / Noura Mohamed Salah Eldin Riad ; Supervised Darius P. Zlotos - Cairo : Noura Mohamed Salah Eldin Riad , 2013 - 140 Leaves ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Numerous functions of the neurohormone melatonin are mediated through activation of the G - protein - coupled receptors MT₁⁻ and MT₂. Elucidation of the pathophysiological function of the MT₁ receptor has been hampered mainly by the limited availability of selective full agonist and full antagonist for this receptor subtype. Design and synthesis of selective MT₁ receptor ligands with higher affinity and selectivity may contribute to better understanding of physiological functions mediated by MT₁ receptors