Protective effects of certain pharmacological agents in monocrotaline - induced pulmonary hypertension in rats /
Alarqam Zaki Obaid Almohammedi
Protective effects of certain pharmacological agents in monocrotaline - induced pulmonary hypertension in rats / دراسة التأثيراث الواقية لبعض العوامل الدوائية فى الإصابة الناجمة عن ارتفاع ضغط الدم الرئوى بإستخدام مونوكروتالين فى الجرذان Alarqam Zaki Obaid Almohammedi ; Supervised Azza Mounir Agha , Hala Fahmy Zaki , Lamiaa Ahmed Ahmed Attia - Cairo : Alarqam Zaki Obaid Almohammedi , 2014 - 201 P. ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
The pulmonary hypertension is a progressive disease of various origins that is characterized by the elevation of pulmonary arterial pressure and death due to right ventricular dysfunction. In the present study, the possible protective effect of L- arginine, diosgenin and naringenin were investigated in monocrotaline - induced pulmonary hypertension in rats. Pulmonary hypertension was induced by a single subcutaneous injection of monocrotaline (60 mg/kg). Oral doses of L- arginine (500 mg / kg), diosgenin (100 mg / kg) and naringenin (50 mg / kg) alone or in combination were daily administered for 3 weeks. At the end of the experiment, mean arterial blood pressure, electrocardiography and echocardiography were recorded. Rats were then sacrificed and serum was separated for determination of total nitrate / nitrite level
Diosgenin L- arginine Monocrotaline
Protective effects of certain pharmacological agents in monocrotaline - induced pulmonary hypertension in rats / دراسة التأثيراث الواقية لبعض العوامل الدوائية فى الإصابة الناجمة عن ارتفاع ضغط الدم الرئوى بإستخدام مونوكروتالين فى الجرذان Alarqam Zaki Obaid Almohammedi ; Supervised Azza Mounir Agha , Hala Fahmy Zaki , Lamiaa Ahmed Ahmed Attia - Cairo : Alarqam Zaki Obaid Almohammedi , 2014 - 201 P. ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
The pulmonary hypertension is a progressive disease of various origins that is characterized by the elevation of pulmonary arterial pressure and death due to right ventricular dysfunction. In the present study, the possible protective effect of L- arginine, diosgenin and naringenin were investigated in monocrotaline - induced pulmonary hypertension in rats. Pulmonary hypertension was induced by a single subcutaneous injection of monocrotaline (60 mg/kg). Oral doses of L- arginine (500 mg / kg), diosgenin (100 mg / kg) and naringenin (50 mg / kg) alone or in combination were daily administered for 3 weeks. At the end of the experiment, mean arterial blood pressure, electrocardiography and echocardiography were recorded. Rats were then sacrificed and serum was separated for determination of total nitrate / nitrite level
Diosgenin L- arginine Monocrotaline