Study of the possible protective effect (s) of certain antioxidants against cadmium induced teratogenicity in experimental animals /
Hoda Samir Badr
Study of the possible protective effect (s) of certain antioxidants against cadmium induced teratogenicity in experimental animals / دراسة التأثيرات المحتملة لبعض مضادات الاكسدة فى تشوهات الأجنة المحدثه من عنصر الكادميوم فى حيوانات التجارب Hoda Samir Badr ; Supervised Afaf A. Ain Shoka , Asmaa M. Kandil , Noha N. Nassar - Cairo : Hoda Samir Badr , 2014 - 195 P. : charts , photographs ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
This work investigates the possible protective role of curcumin and selenium (Se), considered as antioxidants, singly or in combination in ameliorating cadmium (Cd) induced teratogenicity. Cadmium (18.4mg / kg, p.o) was given from day 7 to 16 of gestation. Curcumin (50mg / kg, p.o), Se (18æg / Kg, p.o) or their combination were administered all over the period of gestation with or without Cd insult. The results showed decrease in maternal body weight gain, increase in the rate of abortion, resorption and growth retardation of fetuses and malformations in their skeleton in group received Cd. Besides, there were significant decrease in red blood cells, and hemoglobin concentration while increase in the white blood cells count. Serum levels of AST, ALT, LDH, urea and creatinine showed significant elevation in mothers and their fetuses compared to the normal control group
Cadmium Curcumin Selenium
Study of the possible protective effect (s) of certain antioxidants against cadmium induced teratogenicity in experimental animals / دراسة التأثيرات المحتملة لبعض مضادات الاكسدة فى تشوهات الأجنة المحدثه من عنصر الكادميوم فى حيوانات التجارب Hoda Samir Badr ; Supervised Afaf A. Ain Shoka , Asmaa M. Kandil , Noha N. Nassar - Cairo : Hoda Samir Badr , 2014 - 195 P. : charts , photographs ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
This work investigates the possible protective role of curcumin and selenium (Se), considered as antioxidants, singly or in combination in ameliorating cadmium (Cd) induced teratogenicity. Cadmium (18.4mg / kg, p.o) was given from day 7 to 16 of gestation. Curcumin (50mg / kg, p.o), Se (18æg / Kg, p.o) or their combination were administered all over the period of gestation with or without Cd insult. The results showed decrease in maternal body weight gain, increase in the rate of abortion, resorption and growth retardation of fetuses and malformations in their skeleton in group received Cd. Besides, there were significant decrease in red blood cells, and hemoglobin concentration while increase in the white blood cells count. Serum levels of AST, ALT, LDH, urea and creatinine showed significant elevation in mothers and their fetuses compared to the normal control group
Cadmium Curcumin Selenium