The prognostic value of adenosine triphosphate (ATP) binding Cassette (ABCB5) and Multidrug resistance (MDR1) genes` expression in acute leukemias /
Hebat Allah Ahmed Mahmoud Ahmed
The prognostic value of adenosine triphosphate (ATP) binding Cassette (ABCB5) and Multidrug resistance (MDR1) genes` expression in acute leukemias / القيمه التعبيريه و النذيره لجينات ادينوسين ثلاثى الفوسفات كاسيت الملزم (ايه بى س بى 5) و لتحديد المقاومه المتعدده للادويه1(ام دى ار 1) فى سرطان الدم الحاد Hebat Allah Ahmed Mahmoud Ahmed ; Supervised Hala M. Farawela , Hamdy M. Zawam , Mervat M. Khorshied - Cairo : Hebat Allah Ahmed Mahmoud Ahmed , 2014 - 264 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Multidrug resistance represents a major obstacle in the chemotherapeutic treatment of acute leukemia (AL). Adenosine triphosphate ATP - binding cassette (ABCB5) and multidrug resistance (MDR1) genes are integral membrane proteins belonging to ATP - binding cassette transporters superfamily. The present work aimed to investigate the impact of ABCB5 and MDR1 genes expression on the response to chemotherapy in a cohort of Egyptian acute leukemia patients. The study included 90 patients; 53 AML cases and 37 ALL cases in addition to 20 healthy volunteers as controls. Quantitative assessment of MDR1 and ABCB5 genes expression was performed by quantitative real-time polymerase chain reaction qPCR
ABCB5 Gene expression MDR1
The prognostic value of adenosine triphosphate (ATP) binding Cassette (ABCB5) and Multidrug resistance (MDR1) genes` expression in acute leukemias / القيمه التعبيريه و النذيره لجينات ادينوسين ثلاثى الفوسفات كاسيت الملزم (ايه بى س بى 5) و لتحديد المقاومه المتعدده للادويه1(ام دى ار 1) فى سرطان الدم الحاد Hebat Allah Ahmed Mahmoud Ahmed ; Supervised Hala M. Farawela , Hamdy M. Zawam , Mervat M. Khorshied - Cairo : Hebat Allah Ahmed Mahmoud Ahmed , 2014 - 264 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Multidrug resistance represents a major obstacle in the chemotherapeutic treatment of acute leukemia (AL). Adenosine triphosphate ATP - binding cassette (ABCB5) and multidrug resistance (MDR1) genes are integral membrane proteins belonging to ATP - binding cassette transporters superfamily. The present work aimed to investigate the impact of ABCB5 and MDR1 genes expression on the response to chemotherapy in a cohort of Egyptian acute leukemia patients. The study included 90 patients; 53 AML cases and 37 ALL cases in addition to 20 healthy volunteers as controls. Quantitative assessment of MDR1 and ABCB5 genes expression was performed by quantitative real-time polymerase chain reaction qPCR
ABCB5 Gene expression MDR1