Alzheimer's disease and type 2 diabetes mellitus : Vascular and metabolic determinants /
Amal Sayed Ashour Ali
Alzheimer's disease and type 2 diabetes mellitus : Vascular and metabolic determinants / مرض الزهايمر و النوع الثانى للبول السكرى : العوامل الوعائية و الأيضية Amal Sayed Ashour Ali ; Supervised Azza Abbas Helmy , Hosna Mohammed Moustafa , Faisal Abdelwahab Atta - Cairo : Amal Sayed Ashour Ali , 2014 - 322 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry
Epidemiological and basic science evidence suggest a possible shared pathophysiology between type 2 diabetes mellitus (T2DM) and alzheimer's dementia (AD). Compare between type 2 diabetic, non diabetic AD and control regarding cognitive functions and metabolic abnormalities, assess cerebral blood flow (CBF) and correlate it with the severity of both DM and AD. Three groups were included. group (Gr) I: 20 patients with AD + DM, Gr II: 26 patients with AD only and were matched with Gr III: including 20 normal control (NC). The following were done for all patients: A battery of neuropsychological tests, laboratory tests (lipid profile, serum uric acid, fasting blood glucose, post prandial blood glucose, glycosated hemoglobin, insulin level, insulin resistance and serum insulin like growth factor 1) then assessment of CBF using extracranial carotid duplex (ECD) and single photon emission computerized tomography SPECT
AD SPECT T2DM
Alzheimer's disease and type 2 diabetes mellitus : Vascular and metabolic determinants / مرض الزهايمر و النوع الثانى للبول السكرى : العوامل الوعائية و الأيضية Amal Sayed Ashour Ali ; Supervised Azza Abbas Helmy , Hosna Mohammed Moustafa , Faisal Abdelwahab Atta - Cairo : Amal Sayed Ashour Ali , 2014 - 322 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry
Epidemiological and basic science evidence suggest a possible shared pathophysiology between type 2 diabetes mellitus (T2DM) and alzheimer's dementia (AD). Compare between type 2 diabetic, non diabetic AD and control regarding cognitive functions and metabolic abnormalities, assess cerebral blood flow (CBF) and correlate it with the severity of both DM and AD. Three groups were included. group (Gr) I: 20 patients with AD + DM, Gr II: 26 patients with AD only and were matched with Gr III: including 20 normal control (NC). The following were done for all patients: A battery of neuropsychological tests, laboratory tests (lipid profile, serum uric acid, fasting blood glucose, post prandial blood glucose, glycosated hemoglobin, insulin level, insulin resistance and serum insulin like growth factor 1) then assessment of CBF using extracranial carotid duplex (ECD) and single photon emission computerized tomography SPECT
AD SPECT T2DM