Neurobehavioral study on an animal model of multiple sclerosis /
Heba Mohamed Fahmy Abdelbaky
Neurobehavioral study on an animal model of multiple sclerosis / دراسة السلوك العصبى على نموذج حيوانى لمرض التصلب المتعدد Heba Mohamed Fahmy Abdelbaky ; Supervised Anwar Abdelazim Elsayed , Nasr Mahmoud Radwan , Neveen Amin Noor - Cairo : Heba Mohamed Fahmy Abdelbaky , 2014 - 147 Leaves : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics
Multiple sclerosis (MS) is an immune mediated, inflammatory demyelinating neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a well- established animal model of MS. The aim of the present study is to investigate the protective and therapeutic effects of Nigella sativa (N. sativa) seeds (2.8 g / kg body weight) in EAE-induced rats. EAE was induced by single subcutaneous injection in the tail base with 100 æg myelin oligodendrocyte glycoprotein (MOG) in complete Freund's adjuvant (CFA) containing 1 mg / ml of Mycobacterium tuberculosis. Animals immunized with MOG were divided into 3 groups: 1- EAE-induced animals (2EAE3 group) received daily oral administration of distilled water until the end of the experiment. 2- The animals of the second group (2N. sativa + EAE3 group) received daily oral administration of N. sativa 2 weeks prior EAE induction till the end of the experiment. 3- Animals of the third group (2EAE + N. sativa3 group) received daily oral administration of N. sativa after the appearance of first clinical signs until the end of the experiment
Demyelination Experimental autoimmune encephalomyelitis (EAE) Nigella sativa (N.sativa)
Neurobehavioral study on an animal model of multiple sclerosis / دراسة السلوك العصبى على نموذج حيوانى لمرض التصلب المتعدد Heba Mohamed Fahmy Abdelbaky ; Supervised Anwar Abdelazim Elsayed , Nasr Mahmoud Radwan , Neveen Amin Noor - Cairo : Heba Mohamed Fahmy Abdelbaky , 2014 - 147 Leaves : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics
Multiple sclerosis (MS) is an immune mediated, inflammatory demyelinating neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a well- established animal model of MS. The aim of the present study is to investigate the protective and therapeutic effects of Nigella sativa (N. sativa) seeds (2.8 g / kg body weight) in EAE-induced rats. EAE was induced by single subcutaneous injection in the tail base with 100 æg myelin oligodendrocyte glycoprotein (MOG) in complete Freund's adjuvant (CFA) containing 1 mg / ml of Mycobacterium tuberculosis. Animals immunized with MOG were divided into 3 groups: 1- EAE-induced animals (2EAE3 group) received daily oral administration of distilled water until the end of the experiment. 2- The animals of the second group (2N. sativa + EAE3 group) received daily oral administration of N. sativa 2 weeks prior EAE induction till the end of the experiment. 3- Animals of the third group (2EAE + N. sativa3 group) received daily oral administration of N. sativa after the appearance of first clinical signs until the end of the experiment
Demyelination Experimental autoimmune encephalomyelitis (EAE) Nigella sativa (N.sativa)