The influence of immunoglobulin IgG Fc - receptor polymorphisms on susceptibility to guillain - barre{u00B4} syndrome /
Mohamed Abdulhay Ahmed Masoud
The influence of immunoglobulin IgG Fc - receptor polymorphisms on susceptibility to guillain - barre syndrome / تأثير تنوع أشكال المستقبلات للأجسام المناعية ج فى الإستعداد لحدوث متلازمة جيلان باريه Mohamed Abdulhay Ahmed ; Supervised Lobna Abdelgawad Mansour , Marian Yousry Fahmy , Mariam Onsy Farag - Cairo : Mohamed Abdulhay Ahmed Masoud , 2014 - 142 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics
Macrophages and ganglioside-specific immunoglobulin G (IgG) are involved in the pathogenesis of guillain - barre syndrome (GBS). Leukocyte IgG receptors (FcÞR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG - mediated cellular inflammatory responses is determined by functional polymorphisms of three FcÞR subclasses (FcÞRIIA: H131/R131; FcÞRIIIA: V158 / F158; FcÞRIIIB: NA1/NA2). FcÞR genotype distributions were determined in some cohorts of GBS patients and controls. The purpose of our study was mainly to investigate the role of the host immunogenetic factors like high affinity FcÞR polymorphism in the development of GBS compared to controls and their association with commonly described antecedent infections, electrophysiological subtypes, severity and outcome of GBS
FcÞR Guillain barre syndrome Polymorphism
The influence of immunoglobulin IgG Fc - receptor polymorphisms on susceptibility to guillain - barre syndrome / تأثير تنوع أشكال المستقبلات للأجسام المناعية ج فى الإستعداد لحدوث متلازمة جيلان باريه Mohamed Abdulhay Ahmed ; Supervised Lobna Abdelgawad Mansour , Marian Yousry Fahmy , Mariam Onsy Farag - Cairo : Mohamed Abdulhay Ahmed Masoud , 2014 - 142 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics
Macrophages and ganglioside-specific immunoglobulin G (IgG) are involved in the pathogenesis of guillain - barre syndrome (GBS). Leukocyte IgG receptors (FcÞR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG - mediated cellular inflammatory responses is determined by functional polymorphisms of three FcÞR subclasses (FcÞRIIA: H131/R131; FcÞRIIIA: V158 / F158; FcÞRIIIB: NA1/NA2). FcÞR genotype distributions were determined in some cohorts of GBS patients and controls. The purpose of our study was mainly to investigate the role of the host immunogenetic factors like high affinity FcÞR polymorphism in the development of GBS compared to controls and their association with commonly described antecedent infections, electrophysiological subtypes, severity and outcome of GBS
FcÞR Guillain barre syndrome Polymorphism