Enantioseparation and quantitative determination of some chiral switching drugs /
Lobna Mohammed Abdelhalim
Enantioseparation and quantitative determination of some chiral switching drugs / الفصل الإنتقائى و التحليل الكمى لبعض الأدوية ذات خاصية التماثل المرأوى Lobna Mohammed Abdelhalim ; Supervised Laila Elsayed Abdelfattah , Maissa Yacoub Salem , Nahla Nour Eldin Ahmed Salama - Cairo : Lobna Mohammed Abdelhalim , 2015 - 264 P. : facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry
The aim of this work is development and validation of new analytical techniques for enantioseparation and quantitative determination of some chiral switching drugs. In this thesis, zopiclone, ofloxacin, atracurium mesylate, ibuprofen, atropine sulphate, ketoprofen, and citalopram, were chosen to be studied as representative examples of chiral switching drugs to pure isomers, eszopiclone, levofloxacin, cisatracurium mesylate, dexibuprofen, hyoscyamine sulphate, dexketoprofen, escitalopram oxalate. The accuracy, selectivivity and applicability of the developed methods to the determination of enantiomeric purity and assay of chiral drugs in drug substances and drug products in QC laboratories were also studied
Enantiomer separation Ofloxacin Zopiclone
Enantioseparation and quantitative determination of some chiral switching drugs / الفصل الإنتقائى و التحليل الكمى لبعض الأدوية ذات خاصية التماثل المرأوى Lobna Mohammed Abdelhalim ; Supervised Laila Elsayed Abdelfattah , Maissa Yacoub Salem , Nahla Nour Eldin Ahmed Salama - Cairo : Lobna Mohammed Abdelhalim , 2015 - 264 P. : facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry
The aim of this work is development and validation of new analytical techniques for enantioseparation and quantitative determination of some chiral switching drugs. In this thesis, zopiclone, ofloxacin, atracurium mesylate, ibuprofen, atropine sulphate, ketoprofen, and citalopram, were chosen to be studied as representative examples of chiral switching drugs to pure isomers, eszopiclone, levofloxacin, cisatracurium mesylate, dexibuprofen, hyoscyamine sulphate, dexketoprofen, escitalopram oxalate. The accuracy, selectivivity and applicability of the developed methods to the determination of enantiomeric purity and assay of chiral drugs in drug substances and drug products in QC laboratories were also studied
Enantiomer separation Ofloxacin Zopiclone