Analytical study of some psychotropic drugs /
Christine Maged Abdou Elmaraghy
Analytical study of some psychotropic drugs / دراسة تحليلية على بعض الأدوية النفسية Christine Maged Abdou Elmaraghy ; Supervised Sawsan Mohamed Mohamed Amer , Hesham Salem Sharaf Eldin , Marianne Nebsen Morcos - Cairo : Christine Maged Abdou Elmaraghy , 2015 - 264 P. ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry
This thesis was to develop accurate,sensitive and validated spectrophotometric, chemometric, electrochemical, TLC- densitometric and HPLC methods for quantitative determination of three psychotropic drugs namely; Quetiapine fumarate in presence of its related compounds, Citalopram hydrobromide in presence of its degradation products and Clonazepam drug and Aripiprazole in presence of its degradation products. and simultaneous determination of Aripiprazole and co-administered Clonazepam in human plasma. The proposed methods were validated according to the ICH guidelines. The obtained results were statistically comparedwith those obtained from the reference HPLC method, showing no significant difference with respect to accuracy and precision
Aripiprazole Citalopram hydrobromide Quetiapine fumarate
Analytical study of some psychotropic drugs / دراسة تحليلية على بعض الأدوية النفسية Christine Maged Abdou Elmaraghy ; Supervised Sawsan Mohamed Mohamed Amer , Hesham Salem Sharaf Eldin , Marianne Nebsen Morcos - Cairo : Christine Maged Abdou Elmaraghy , 2015 - 264 P. ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry
This thesis was to develop accurate,sensitive and validated spectrophotometric, chemometric, electrochemical, TLC- densitometric and HPLC methods for quantitative determination of three psychotropic drugs namely; Quetiapine fumarate in presence of its related compounds, Citalopram hydrobromide in presence of its degradation products and Clonazepam drug and Aripiprazole in presence of its degradation products. and simultaneous determination of Aripiprazole and co-administered Clonazepam in human plasma. The proposed methods were validated according to the ICH guidelines. The obtained results were statistically comparedwith those obtained from the reference HPLC method, showing no significant difference with respect to accuracy and precision
Aripiprazole Citalopram hydrobromide Quetiapine fumarate