Synthesis and anti tumor evaluation of Heterocyclic compounds synthesized from Ý-diketone and active methylene derivatives /
Marwa Soliman Gaman Salama
Synthesis and anti tumor evaluation of Heterocyclic compounds synthesized from Ý-diketone and active methylene derivatives / تحضير و قياس مضادات الأورام لمركبات غير متجانسة الحلقة محضرة من مشتقات البيتا ثنائى الكيتون و الميثيلين النشطة Marwa Soliman Gaman Salama ; Supervised Rafat Milad Mohareb - Cairo : Marwa Soliman Gaman Salama , 2016 - 120 P. ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
In this work the reaction of O-phenylenediamine (1) with diethylmalonate (2) in an oil bath at 120 C gave ethyl 2- (1H-benzo [d] imidazol-2-yl) acetate (3). Compound 3 was used in many acyclic and heterocyclic reactions. The latter products underwent a series of heterocyclization reactions to yield pyrazole, thiophene, pyridine and coumarin derivatives. The antitumor evaluations of the newly synthesized products against three cancer cell lines were measured
Benzimidazole compounds Heterocycles Synthesis
Synthesis and anti tumor evaluation of Heterocyclic compounds synthesized from Ý-diketone and active methylene derivatives / تحضير و قياس مضادات الأورام لمركبات غير متجانسة الحلقة محضرة من مشتقات البيتا ثنائى الكيتون و الميثيلين النشطة Marwa Soliman Gaman Salama ; Supervised Rafat Milad Mohareb - Cairo : Marwa Soliman Gaman Salama , 2016 - 120 P. ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
In this work the reaction of O-phenylenediamine (1) with diethylmalonate (2) in an oil bath at 120 C gave ethyl 2- (1H-benzo [d] imidazol-2-yl) acetate (3). Compound 3 was used in many acyclic and heterocyclic reactions. The latter products underwent a series of heterocyclization reactions to yield pyrazole, thiophene, pyridine and coumarin derivatives. The antitumor evaluations of the newly synthesized products against three cancer cell lines were measured
Benzimidazole compounds Heterocycles Synthesis