Phytochemicals as innovative drug leads in molecular targeted therapy of hepatocellular carcinoma /
Yasmine Mostafa Mohamed Ibrahim Shaalan
Phytochemicals as innovative drug leads in molecular targeted therapy of hepatocellular carcinoma / Yasmine Mostafa Mohamed Ibrahim Shaalan ; Supervised Hend Eltayebi , Ahmed Ihab Abdelaziz , Heba Handoussa - Cairo : Yasmine Mostafa Mohamed Ibrahim Shaalan , 2016 - 138 Leaves ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceulical Biology
Background: There has been an alarming increase in the burden of hepatocellular carcinoma (HCC) in Egypt. The IGF axis has emerged as one of the key players in HCC pathogenesis. IGF2BP1 and IGF2BP3 belong to family of oncogenic RNA-binding protiens, highly up-regulated in HCC. IGF2BPs influence their transcript target's fate by caging their target mRNA in cytoplasmic protein-RNA complexes, which provide a bona fide mechanism to prevent the premature decay or enhance the translation of specific target transcripts, including IGF2. Extensive evidence suggest that miRNAs play critical roles in cancer progression and specifically in regulating the IGF axis members
Hepatocellular carcinoma Innovative drug Molecular targeted therapy
Phytochemicals as innovative drug leads in molecular targeted therapy of hepatocellular carcinoma / Yasmine Mostafa Mohamed Ibrahim Shaalan ; Supervised Hend Eltayebi , Ahmed Ihab Abdelaziz , Heba Handoussa - Cairo : Yasmine Mostafa Mohamed Ibrahim Shaalan , 2016 - 138 Leaves ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceulical Biology
Background: There has been an alarming increase in the burden of hepatocellular carcinoma (HCC) in Egypt. The IGF axis has emerged as one of the key players in HCC pathogenesis. IGF2BP1 and IGF2BP3 belong to family of oncogenic RNA-binding protiens, highly up-regulated in HCC. IGF2BPs influence their transcript target's fate by caging their target mRNA in cytoplasmic protein-RNA complexes, which provide a bona fide mechanism to prevent the premature decay or enhance the translation of specific target transcripts, including IGF2. Extensive evidence suggest that miRNAs play critical roles in cancer progression and specifically in regulating the IGF axis members
Hepatocellular carcinoma Innovative drug Molecular targeted therapy