Design , synthesis of symmetric molecules as potential anti-HCV agents /

Alaa Rizk Sanad Ibrahim Leila

Design , synthesis of symmetric molecules as potential anti-HCV agents / تصميم وتحضير الجزيئات المتماثلة المضادة لفيروس سي Alaa Rizk Sanad Ibrahim Leila ; Supervised Ashraf H. Abadi , Mohammad Abdelhalim - Cairo : Alaa Rizk Sanad Ibrahim Leila , 2017 - 101 Leaves : charts , facsimiles ; 30cm

Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Until recently, the standard therapy for HCV treatment has been a combination of interferon Ü (IFNÜ) and ribavirin (RBV) which has severe side effects and contraindications. Cure rates reported for this combination therapy were about 50%¹² therefore, direct-acting antivirals (DAAs) were developed to target viral proteins that are crucial for the HCV lifecycle
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