Study of the treatment of cutaneous fungal infection in animal model using photoactivated composite of methylene blue and metal nanoparticle /
Islam Mohamed Noaman Mohamed
Study of the treatment of cutaneous fungal infection in animal model using photoactivated composite of methylene blue and metal nanoparticle / علاج الفطريات الجلدية في نموذج حيواني باستخدام مركب الميثيلين الأزرق وجسيمات النانو المعدنية المستحثة بالضوء Islam Mohamed Noaman Mohamed ; Supervised Mona Mohamed Soliman , Abeer Attia Tawfik ,Hassan Ibraheem H. Elsayyad - Cairo : Islam Mohamed Noaman Mohamed , 2018 - 78 P. : facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Applications in Medical and Biological
Background: Onychomycosis is a widespread public health problem, in which T. rubrum and T. mentagro-phytes is the commenest causative organisms. Current medical therapy has many drawbacks and sideeffects. Methylene blue (m.b) photodynamic therapy (pdt) proved efficacy but with lengthy sessions.Objectives: Optimizing methylene blue photodynamic therapy by combination of methylene blue pho-tosensitizer and gold nanoparticles (aunps) in a composite as gold nanoparticles are efficient delivery systems and efficient enhancers of photosensitizers for antifungal photodynamic therapy. Materials and methods: Eighty newzealand rabbit (Oryctolagus cuniculus) were used and categorized ineight equal groups as follows; healthy and infection control, composite photodynamic therapy and five comparative groups. Photodynamic therapy was initiated at day three to five post inoculation, for four sessions forty-eight hours apart. Each group divided and light exposure at two fluencies; 80 J and 100 J. All groups were investigated macroscopically and microscopically (histopathology and scanning electron microscope) also flowcytometry assessment for cell death and X-ray analysis for gold nanoparticles accumulation in brain and liver tissues were determined
Dermatophytosis Methylene blue photodynamic therapy Onychomycosis
Study of the treatment of cutaneous fungal infection in animal model using photoactivated composite of methylene blue and metal nanoparticle / علاج الفطريات الجلدية في نموذج حيواني باستخدام مركب الميثيلين الأزرق وجسيمات النانو المعدنية المستحثة بالضوء Islam Mohamed Noaman Mohamed ; Supervised Mona Mohamed Soliman , Abeer Attia Tawfik ,Hassan Ibraheem H. Elsayyad - Cairo : Islam Mohamed Noaman Mohamed , 2018 - 78 P. : facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Applications in Medical and Biological
Background: Onychomycosis is a widespread public health problem, in which T. rubrum and T. mentagro-phytes is the commenest causative organisms. Current medical therapy has many drawbacks and sideeffects. Methylene blue (m.b) photodynamic therapy (pdt) proved efficacy but with lengthy sessions.Objectives: Optimizing methylene blue photodynamic therapy by combination of methylene blue pho-tosensitizer and gold nanoparticles (aunps) in a composite as gold nanoparticles are efficient delivery systems and efficient enhancers of photosensitizers for antifungal photodynamic therapy. Materials and methods: Eighty newzealand rabbit (Oryctolagus cuniculus) were used and categorized ineight equal groups as follows; healthy and infection control, composite photodynamic therapy and five comparative groups. Photodynamic therapy was initiated at day three to five post inoculation, for four sessions forty-eight hours apart. Each group divided and light exposure at two fluencies; 80 J and 100 J. All groups were investigated macroscopically and microscopically (histopathology and scanning electron microscope) also flowcytometry assessment for cell death and X-ray analysis for gold nanoparticles accumulation in brain and liver tissues were determined
Dermatophytosis Methylene blue photodynamic therapy Onychomycosis