Assessment of some angiogenic markers in hepatitis C infected patients after therapy /
Mohamed Taher Mahmoud Ali
Assessment of some angiogenic markers in hepatitis C infected patients after therapy / تقييم بعض دلالات تكوين اوعية دموية جديدة في مرضى الالتهاب الكبدى الوبائى سى بعد العلاج Mohamed Taher Mahmoud Ali ; Supervised Ahmed Ibrahim Amin , Elshahat Abomosalam Toson , Abdou Osman Abdelhamid - Cairo : Mohamed Taher Mahmoud Ali , 2020 - 149 P . : charts , facsmilies ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry
The assessment of liver fibrosis by non-invasive methods before and after treatment is clinically important where hepatitis C virus (HCV) is common in Egypt. Aim: The efficacy of the combined treatment sofosbuvir and ribavirin on HCV infected patients by evaluate the mean serum levels of some direct markers such as Laminin (LN) as fibrogenic marker and platelets derived growth factor (PDGF) and Angiopoietin-1 (Ang-1) as angiogenic markers before and after treatment for the same patients and indirect markers were also included. Also, trying to assess the ability of Ang-1 as a direct marker to differentiate between significant and non-significant fibrosis and the results were compared with those of indirect published score AST/ALT ratio (AAR).This study implying significantly decreased in the mean serum levels of laminin, platelet derived growth factor and angiopoietin-1after treatment. Thus, can be used to assess treatment response and improved liver condition. Also, we found that Ang-1 can help in assessing hepatic fibrosis and superior to AAR score in discriminating the stages of the liver disorders in CHC Egyptian patients
Angiopoietin- 1 Diagnostic performance Liver fibrosis
Assessment of some angiogenic markers in hepatitis C infected patients after therapy / تقييم بعض دلالات تكوين اوعية دموية جديدة في مرضى الالتهاب الكبدى الوبائى سى بعد العلاج Mohamed Taher Mahmoud Ali ; Supervised Ahmed Ibrahim Amin , Elshahat Abomosalam Toson , Abdou Osman Abdelhamid - Cairo : Mohamed Taher Mahmoud Ali , 2020 - 149 P . : charts , facsmilies ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry
The assessment of liver fibrosis by non-invasive methods before and after treatment is clinically important where hepatitis C virus (HCV) is common in Egypt. Aim: The efficacy of the combined treatment sofosbuvir and ribavirin on HCV infected patients by evaluate the mean serum levels of some direct markers such as Laminin (LN) as fibrogenic marker and platelets derived growth factor (PDGF) and Angiopoietin-1 (Ang-1) as angiogenic markers before and after treatment for the same patients and indirect markers were also included. Also, trying to assess the ability of Ang-1 as a direct marker to differentiate between significant and non-significant fibrosis and the results were compared with those of indirect published score AST/ALT ratio (AAR).This study implying significantly decreased in the mean serum levels of laminin, platelet derived growth factor and angiopoietin-1after treatment. Thus, can be used to assess treatment response and improved liver condition. Also, we found that Ang-1 can help in assessing hepatic fibrosis and superior to AAR score in discriminating the stages of the liver disorders in CHC Egyptian patients
Angiopoietin- 1 Diagnostic performance Liver fibrosis