The value of magnetic resonance imaging in early detection of chemotherapeutic neurotoxicity in pediatric cancer patients /
Mo`mena Abdelaziz Abdou Mohamed
The value of magnetic resonance imaging in early detection of chemotherapeutic neurotoxicity in pediatric cancer patients / قيمة التصوير بالرنين المغناطيسى فى الاكتشاف المبكر للاثار السمية للعلاج الكيماوى على الجهاز العصبى المركزى عند الاطفال المرضى بالسرطان Mo'mena Abdelaziz Abdou Mohamed ; Supervised Hassan Aly Elkiki , Ayda Aly Youssef , Youssef Madani Said - Cairo : Mo'mena Abdelaziz Abdou Mohamed , 2019 - 169 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Radio-diagnosis
Cancer is the second most common cause of death among children aged 1 to 18 years in the United States, surpassed only by accidents.Treatment-related neurotoxicity is a potentially life threatening clinical condition that can represent a diagnostic challenge. Differentiating diagnoses between therapy associated brain injury and recurrent disease can be difficult, and the immediate recognition of neurotoxicity is crucial to provide correct therapeutic management, ensuring damage reversibility.Purpose: Is to make radiologists aware of chemotherapy neurotoxicities and early detection of it using MRI & its early management to prevent permanent damage. Patients and methods: We evaluated 63pediatric patients with suspected neurotoxicity related to chemotherapy treatment. MR examinations were performed with a 1.5-T system. MRI data was collected and correlated with clinical data. Results:41 patients diagnosed as PRES with 8 patients had typical MRI criteria and 33 patients have atypical criteria, 16 patients diagnosed as cerebral venous sinus thrombosis with MRV is the most important sequence to diagnose CVST and finally 6 patients diagnosed as methotrexate neurotoxicity with DWI is the most important sequence for early diagnosis
Chemotherapy CNS MRI
The value of magnetic resonance imaging in early detection of chemotherapeutic neurotoxicity in pediatric cancer patients / قيمة التصوير بالرنين المغناطيسى فى الاكتشاف المبكر للاثار السمية للعلاج الكيماوى على الجهاز العصبى المركزى عند الاطفال المرضى بالسرطان Mo'mena Abdelaziz Abdou Mohamed ; Supervised Hassan Aly Elkiki , Ayda Aly Youssef , Youssef Madani Said - Cairo : Mo'mena Abdelaziz Abdou Mohamed , 2019 - 169 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Radio-diagnosis
Cancer is the second most common cause of death among children aged 1 to 18 years in the United States, surpassed only by accidents.Treatment-related neurotoxicity is a potentially life threatening clinical condition that can represent a diagnostic challenge. Differentiating diagnoses between therapy associated brain injury and recurrent disease can be difficult, and the immediate recognition of neurotoxicity is crucial to provide correct therapeutic management, ensuring damage reversibility.Purpose: Is to make radiologists aware of chemotherapy neurotoxicities and early detection of it using MRI & its early management to prevent permanent damage. Patients and methods: We evaluated 63pediatric patients with suspected neurotoxicity related to chemotherapy treatment. MR examinations were performed with a 1.5-T system. MRI data was collected and correlated with clinical data. Results:41 patients diagnosed as PRES with 8 patients had typical MRI criteria and 33 patients have atypical criteria, 16 patients diagnosed as cerebral venous sinus thrombosis with MRV is the most important sequence to diagnose CVST and finally 6 patients diagnosed as methotrexate neurotoxicity with DWI is the most important sequence for early diagnosis
Chemotherapy CNS MRI