Clinicopathological Studies on the Effect of Bone MarrowStem Cells on Experimental Diabetic Rats / (Record no. 163726)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03597nam a2200409Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260615131017.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 2310s2022 ua a frm 000 0 und d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 571.9 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 571.9 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.10.05.Ph.D.2021.Sh.C |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Shereen Youssef Elsayed Abd Elmotaleb Youssef, |
| Preparation | preparation. |
| 245 ## - TITLE STATEMENT | |
| Title | Clinicopathological Studies on the Effect of Bone MarrowStem Cells on Experimental Diabetic Rats / |
| Statement of responsibility, etc. | by Shereen Youssef Elsayed Abd Elmotaleb Youssef; Prof.Dr. Safaa Yassin Sayed Ahmed, Prof.Dr.Shaymaa Ismaeil Salem. |
| 246 ## - VARYING FORM OF TITLE | |
| Title proper/short title | دراسات باثولوجية إكلينيكية على تأثير الخلايا الجذعية النخاعية على الفئران المصابة تجريبيا بالداء السكرى |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2021. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 79 p. : |
| Other physical details | illustrations |
| Dimensions | 25cm |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Source | rda content |
| Content type term | text |
| 337 ## - MEDIA TYPE | |
| Source | rdamedia |
| Media type term | Unmediated |
| 338 ## - CARRIER TYPE | |
| Source | rdacarrier |
| Carrier type term | volume |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo Univsersity,2021 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: P. 68-92 |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Diabetes mellitus is a group of metabolic diseases -multi-systemic disorder- characterized by<br/>hyperglycemia resulting from defects in insulin secretion. The therapeutic treatment with bone<br/>marrow mesenchymal stem cells “BM-MSCs” has a promising value in the management of kidney,<br/>liver and pancreatic degeneration. Fifty male rats were used in this experiment; 5 rats as a source<br/>of BM-MSCs, 5 rats (STZ-diabetic) as the cell tracking and the other 40 rats were randomly<br/>assigned into 4 equal groups; normal control (I), stem cell (II), untreated diabetic (III), and treated<br/>diabetic (BM-MSCs) (IV). To induce DM, rats were intraperitoneally injected single dose of<br/>streptozotocin (STZ) (55 mg/kg BW). The BM-MSCs were collected from 10 rats’ bone marrow,<br/>cultured, characterized using flow cytometry analysis and labeled with Qtracker 655 cell labeling.<br/>BM-MSCs were transplanted in treated diabetic at the 7th day of STZ injection. Rats were<br/>euthanized 4 weeks after STZ injection. Blood samples were collected at the end of experiment<br/>(4th week of BM-MSCs transplantation). The pancreas, kidney and liver tissues were collected.<br/>Hemogram, biochemical parameters (liver & Kidney function tests), insulin gene expression and<br/>histopathological examination of pancreas, liver and kidney, were performed for all experimental<br/>groups. Untreated diabetic group showed significant disturbances in liver, kidney and pancreatic<br/>functions with excessive production of inflammatory cytokine (TNF-α) in kidney tissues and<br/>increased oxidative stress in liver tissues. The BM-MSCs treated diabetic group showed significant<br/>improvement in organs functions, insulin gene expression as well as hematological and<br/>histopathological examinations. In conclusion, treatment with BM-MSCs in diabetic rats improved<br/>the diabetic profile and ameliorated some of its complications. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Diabetes mellitus |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | pathology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Safaa Yassin Sayed Ahmed |
| Relator term | thesis advisor. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shaymaa Ismaeil Salem |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2021 |
| Supervisory body | Safaa Yassin Sayed Ahmed |
| -- | Shaymaa Ismaeil Salem |
| Universities | Cairo University |
| Faculties | Faculty of Veterinary Medicine |
| Department | Department of Clinical Pathology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | 85800 | Cai01.10.05.Ph.D.2021.Sh.C | 01010110085800000 | 30.10.2023 | 30.10.2023 | Thesis |