MARC details
| 000 -LEADER |
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| fixed length control field |
07565namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250223033213.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
231129s2022 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GICUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GICUC |
| Modifying agency |
EG-GICUC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract |
eng |
| -- |
ara |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
615.32 |
| Edition number |
21 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) |
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| Classification number |
615.32 |
| Edition number |
21 |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.08.06.M.Sc.2022.Do.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Doaa Ramadan Mohamed Rizk Hamad, |
| Relator term |
preparation. |
| 245 14 - TITLE STATEMENT |
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| Title |
The potential antimicrobial, immunomodulatory and anticancer activities of selected bioactive plant and fungal products / |
| Statement of responsibility, etc. |
by Doaa Ramadan Mohamed Rizk Hamad ; under supervision of Prof. Dr. Mohammed Abdel Halim Ramadan, Prof. Dr. Wafaa Abdel Allah Ahmed, Asst. Prof. Dr. Heba El Sayed Awed. |
| 246 15 - VARYING FORM OF TITLE |
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| Title proper/short title |
الفاعلية المحتملة لبعض المنتجات الحيوية من النباتات والفطريات كمضادات للميكروبات وللخلايا السرطانية ولتنظيم النشاط المناعي |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Date of production, publication, distribution, manufacture, or copyright notice |
2022. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xv, 162, 7 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
25 cm. + |
| Accompanying material |
CD. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
Unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
volume |
| Source |
rdacarrier |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.)-Cairo University, 2022. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliography: pages 124-162. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
The search for new, promising, and cost-effective medicinal drugs in the field of bioactive metabolites derived from mushrooms and herbs is one strategy for managing resistant pathogens and developing potential anticancer drugs. In the current research, Fruiting bodies of the Pleurotus ostreatus Egyptian-grown polar extract of a fungal species, cold water and ethanol extracts of Flammulina velutipes, and hot water, methanol, and ethanol extracts of herbal Ferula assafoetida were prepared and evaluated for antimicrobial and cytotoxic activity on various cancer cell lines. Four pathogens, including Candida albicans, Staphylococcus aureus, Micrococcus luteus, and Escherichia coli, were effectively overcome by the polar extract of Pleurotus ostreatus. Fusarium oxysporum (47%) and Fusarium solani (28%) as well as Rhizoctonia solani (21%), were found to be inhibited by Pleurotus ostreatus polar extract. Cold water extract of Flammulina velutipes showed antibacterial activity against Micrococcus luteus, Streptococcus pneumoniae, Pseudomonas aeruginosa and Candida albicans. Cold water extract of Flammulina velutipes was found to inhibit Fusarium oxysporum (1.4%) as well as Rhizoctonia solani (3%). Ethanol extract of Flammulina velutipes showed antibacterial activity against Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa and Candida albicans. Ethanol extract of Flammulina velutipes was found to inhibit Fusarium oxysporum (91%), Fusarium solani (59%) as well as Rhizoctonia solani (74%). <br/>The antimicrobial activity of hot water, methanol and ethanol extracts of Ferula assafoetida was studied. All extracts showed antimicrobial activity against Staphylococcus aureus, Micrococcus luteus, Streptococcus pneumoniae and Candida albicans, while hot water extract of Ferula assafoetida only showed antimicrobial activity against Pseudomonas aeruginosa. Hot water extract of Ferula assafoetida was found to inhibit Fusarium oxysporum (5.56%), Fusarium solani (16.67%) as well as Rhizoctonia solani (20%). Methanol extract of Ferula assafoetida was found to inhibit Fusarium oxysporum (72.22%), Fusarium solani (50%) as well as Rhizoctonia solani (42.22%). Ethanol extract of Ferula assafoetida inhibited Fusarium oxysporum (38.89%), Fusarium solani (41.67%) as well as Rhizoctonia solani (36.67%). The antitumor activity of the tested extracts was tested against three cancer cell lines (MCF-7, Hep-G2 and Caco-2). Cytotoxicity was measured and IC50 was determined from a range of concentrations. With the lowest IC50 values (4.5 g/mL) and (0.51mg/mL), respectively, on MCF-7 cells, polar extract of Pleurotus ostreatus and methanol extract of Ferula assafoetida were chosen to study the potential cytotoxic effects. Pleurotus ostreatus polar extract and Ferula assafoetida methanol extract both appeared to promote cell cycle arrest in the sub-G1 stage and apoptosis in MCF-7 cells. Pleurotus ostreatus polar extract markedly enhanced TNF-production while lowering IL-6 levels. The polar extract of Pleurotus ostreatus's total antioxidant capacity, lipid peroxide, and glutathione reductase activity were each measured 0.14 ± 0.02 mM/L, 15.60 ± 0.015 nmol/mL, and 9.50 ± 1.30 U/L, respectively. In MCF-7 cells, Ferula assafoetida methanol extract decreased TNF-α production and IL-6 levels. Ferula assafoetida |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
تهدف هذه الدراسة إلى دراسة الفاعلية البيولوجية لثلاث مستخلصات من فطر المشروم وأيضا من النباتات كمضاد للميكروبات ومنظم للنشاط المناعي ومضاد للسرطان؛ وقد تم استخدام نوعين مختلفين من المشروم، Flammulina velutipes وPleurotus ostreatus، وكذلك نوع من النباتات وهو Ferula assafoetida<br/>وقد اشتملت هذه الدراسة على الآتي<br/>1. تم تحضير مستخلص قطبي من فطر Pleurotus ostreatusومستخلص الماء البارد والايثانول لفطر Flammulina velutipes<br/>2. تم تحضير مستخلصات الماء الساخن والايثانول والميثانول لنبات Ferula assafoetida<br/>3. تم فحص مستخلصات كل من السلالات العشبية والفطرية ضد ثلاثة أنواع من الفطريات الممرضة للتحقق من نشاطها المضاد للفطريات. تم استخدام نسبة تثبيط نمو الفطريات لتحديد التأثير المضاد للفطريات للمستخلصات الخام ضد الفطريات المسببة للأمراض.<br/>4. باستثناء مستخلص الإيثانول من فلاميولينا فيليوتيبس ، فإن جميع المستخلصات المختبرة أعاقت نمو المبيضات البيضاء (Candida albicans).<br/>5. تم قياس النشاط المضاد للبكتريا للمستخلصات موضع الدراسة باستخدام طريقةagar diffusion method)). وقد أظهرت المستخلصات المختبرة في هذه الدراسة درجات مختلفة من التأثير المضاد للبكتريا.<br/>6. تم اختبار النشاط المضاد للأورام للمستخلصات المختبرة ضد ثلاثة أنواع من الخلايا السرطانية (Hep-G2,Caco-2,MCF-7 ) ,تم تحديد قيم IC50لكل مستخلص من خلال مجموعة من التركيزات المختلفة على الخلايا السرطانية.<br/><br/> |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issues also as CD. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medical microbiology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Immunology. |
| 653 #0 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Pleurotus ostreatus |
| -- |
immunomodulatory |
| -- |
cytotoxicity |
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antimicrobial |
| -- |
Ferula assafoetida |
| -- |
Flammulina velutipes |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Heba El Sayed Awed, |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Wafaa Abdel Allah Ahmed, |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohammed Abdel Halim Ramadan, |
| Relator term |
thesis advisor. |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 900 ## - EQUIVALENCE OR CROSS-REFERENCE-PERSONAL NAME [LOCAL, CANADA] |
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| Numeration |
01-01-2022 |
| Titles and other words associated with a name |
Heba El Sayed Awed |
| -- |
Wafaa Abdel Allah Ahmed |
| -- |
Mohammed Abdel Halim Ramadan |
| Universities |
Cairo University |
| Faculties |
Faculty of Pharmacy |
| Divisons |
Department of Pharmaceutical Sciences |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Hanan |
| Reviser |
Essam |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
| Edition |
21 |
| Suppress in OPAC |
No |
