Design, synthesis and biological evaluation of novel benzothiazole derivatives / (Record no. 165959)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05980namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223033217.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 231206s2023 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.31 |
| Edition number | 21 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.31 |
| Edition number | 21 |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.M.Sc.2023.Sa.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sara Sayed Awaad Ahmed, |
| Relator term | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and biological evaluation of novel benzothiazole derivatives / |
| Statement of responsibility, etc. | presented by Sara Sayed Awaad Ahmed ; under the supervision of Prof. Dr. Riham François George, Prof. Dr. Tamer Mohamed Nasr, Dr. Walaa Ramadan Mahmoud. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتشييد وتقييم الفاعلية البيولوجية لبعض مشتقات البنزوثيازول الجديدة |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | xii, 171 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 155-171. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Conventional non-steroidal anti-Inflammatory drugs (NSAIDs) suffer from ulcerogenic tendency resulting in either withdrawal of therapy or severe consequences in patients suffering from rheumatism, arthritis and similar disorders due to gastrointestinal toxicity. On the other hand, some compounds which were introduced in the market as non-ulcerogenic anti-inflammatory drugs by selective inhibition of the induced form of cyclooxygenase (COX-2 inhibitors) have been withdrawn from the international market because of the threat of cardiovascular and central nervous systems side effects, associated with their long-term use. Hence, search for potent and GI-sparing compounds with the ability to inhibit inflammatory responses is still under progress. <br/>Benzothiazole ring is one of the important scaffolds that exhibits various biological and pharmacological activities of which is the anti-inflammatory activity. Accordingly, two series of twenty novel benzothiazole amide derivatives were synthesized namely, aryl vinyl benzamides (IIIa-l) and benzoate derivatives (VIa-h) aiming to produce derivatives with potential anti-inflammatory activity.<br/>The newly synthesized compounds were tested for their in-vivo anti-inflammatory activity using carrageenan-induced rat paw edema, tested compounds IIIb, IIIc, IIIh, VIa and VIe revealed significant anti-inflammatory activities. Furthermore, the ulcerogenic activities was performed on the most active compounds, where VIa and IIIh showed remarkable GIT tolerance. Additionally, the most potent and safe compound VIa was tested for its in-vitro COX enzyme inhibitory activity. Finally, a molecular docking study was conducted to investigate the binding modes of compound VIa in the active sites of COX-1 and COX-2 isoenzymes.<br/> |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | من أكثر العيوب الشائعة لمضادات الالتهاب التقليدية هو تسببها في قرح الجهاز الهضمى وقد تسبب هذا في سحب بعض منها او تطور الاعراض الجانبية عند المرضى اللذين يعانون من الروماتزم وامراض مشابهة أخرى نتيجة تسمم الجهاز الهضمى. من ناحية أخرى بعض المركبات التي استخدمت كمضادات التهابات غير مسببة لقرح الجهاز الهضمى بتثبيطها لإنزيم COX-2 تم سحبها من الأسواق العالمية نظرا لتسببها في امراض القلب والاوعية الدموية والجهاز العصبي المركزي مع طول مدة الاستخدام ولذلك البحث عن مركبات مضادة للالتهاب بدون اثار جانبية على الجهاز الهضمى هو حاجة ملحة.<br/><br/>وتعتبر حلقة البنزوثيازول هي واحدة من اهم الحلقات التي تتميز بالعديد من الأنشطة البيولوجية والفارماكولوجية، من ضمنها نشاطها كمضادات للالتهاب وفقا لذلك تم تشييد سلسلتين من عشرين مركب من مشتقات مختلفة من اميدات البنزوثيازول الجديدة أملاً في الحصول على مركبات فعالة كمضادات التهاب وتم تقسيمها الى مجموعتين، أرايل فينيل بينزامايد (IIIa-l) ومشتقات البنزوات (VIa-h).<br/><br/>هذا وقد تم دراسة النشاط المضاد للالتهاب للمركبات الجديدة على الحيوانات المحقونة بمادة الكاراجينان كمادة مسببة للالتهاب والتورم في الفئران ودراسة قدرتها على التسبب في قرح المعدة بالإضافة الى ذلك تم تقييم نشاط المركب الأكثر فاعلية والأكثر امانا كمثبط لإنزيمي COX-1, COX-2 باستخدام دواء (Indomethacin) كدواء مرجعي وأخيرا تم إجراء الارساء الجزيئي لتوقع تفاعلات اكثر المركبات فاعلية وأكثرها امانا على الجهاز الهضمى مع الاحماض الأمينية في الجزء النشط من إنزيمي COX-1 و COX-2.<br/> |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Language note | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Benzothiazoles. |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pharmaceutical |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Riham François George, |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tamer Mohamed Nasr, |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walaa Ramadan Mahmoud, |
| Relator term | thesis advisor. |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 900 ## - EQUIVALENCE OR CROSS-REFERENCE-PERSONAL NAME [LOCAL, CANADA] | |
| Numeration | 01-01-2023 |
| Titles and other words associated with a name | Riham François George |
| -- | Tamer Mohamed Nasr |
| -- | Walaa Ramadan Mahmoud |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Divisons | Department of Pharmaceutical Sciences |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Hanan |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | Not for loan | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.M.Sc.2023.Sa.D | 01010110087885000 | 06.12.2023 | Thesis |