Selective biomarkers as predictive tools in investigating the efficacy of liposomal Coenzyme- Q10 in the autistic rat model / (Record no. 168380)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05706namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033312.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241013s2023 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposite |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 660.6 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 660.6 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.02.Ph.D.2023.Do.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Doaa Mousa Mostafa Elhefnawei, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Selective biomarkers as predictive tools in investigating the efficacy of liposomal Coenzyme- Q10 in the autistic rat model / |
| Statement of responsibility, etc. | by Doaa Mousa Mostafa Elhefnawei ; Supervisors Prof. Dr. Mohamed Ali El-Desouky , Prof. Dr. Mohamed Ahmed Badawy , Prof. Dr. Ahlam Hosny Mahmoud , Prof. Dr. Mai Osman Mohamed. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | / Coenzyme-Q10 انتقاء المؤشرات الحيوية كدلالات تنبؤية لفاعلية ليبوزومات فى نموذج الجرذان التوحدى |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 121 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 93-121. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Autism spectrum disorder (ASD) is a neurodevelopmental condition with genetic and <br/>environmental origin marked by disturbance in social interaction and repetitive behaviors. <br/>Propionic acid (PPA) is considered as a successful autism animal model. Treatment of <br/>neurodegenerative diseases has tremendous therapeutic potential for Coenzyme-Q10 (CoQ10). <br/>Nevertheless, its low water solubility limited its therapeutic applications. Liposomal drug <br/>delivery possesses the benefits of biocompatibility, targeting organs and avoiding macrophages. <br/>The present study objective is assessing the effectiveness of CoQ10 and liposomal Coenzyme-<br/>Q10 (LCoQ10) on PPA-mediated autistic rat model. Liposomes are efficient for delivering <br/>CoQ10 across the brain-blood barrier (BBB) and reaching the target organ. PPA (500 mg/kg Bw <br/>in phosphate buffer saline) was given daily for five days to induce autism, then receiving therapy <br/>with CoQ10 (10 mg/kg BW) and LCoQ10 (2 mg/kg BW) for 30 days. The model was monitored <br/>for autism symptoms at various time intervals of (one, two and four weeks). Behavioral tests (Y-<br/>Maze and Open field), Gamma-amino butyric acid (GABA), Acetylcholine (ACh), <br/>Acetylcholinesterase (AChE) activity and antioxidant analysis were all accomplished in control, <br/>PPA and treated groups. Glial fibrillary acidic protein (GFAP), Calcium Voltage-Gated Channel <br/>Subunit Alpha 1 C (CACNA1C), Brain-Derived Neurotrophic Factor (BDNF), cAMP Response <br/>Element-Binding Protein (CREB) and Methyl-CpG-binding Protein 2 (MeCP2) gene expression <br/>were also performed. COMET assay and histological examination were also confirmatory. <br/>Superoxide dismutase (SOD), reduced glutathione (GSH), and total antioxidant capacity (TAC) <br/>revealed considerable increases via CoQ10 and LCoQ10 treatment in contrast to MDA. <br/>Moreover, they significantly down regulated GABA, AChE and the gene expression of GFAP, <br/>CACNA1C and BDNF. Furthermore, they up regulated ACh, the gene expression of CREB and <br/>MeCP2. They also improved DNA damage and PPA histopathological abnormalities and <br/>LCoQ10 showed even better results. In conclusion, targeting organs and extending retention time <br/>via LCoQ10 treatment may be a potential technique for limiting aberrant behaviors in PPA-<br/>induced autism rat model. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | اضطراب طيف التوحد (ASD) هو واحد من أكثر الاضطرابات المربكة ل<br/>التي لم يتم تحديد سبب محدد فحسب ، بل لم يتم أيضا تحديد أي علاج نهائي لها<br/>تم العثور عليها حتى الآن. التوحد هو اضطراب يتم ملاحظته عادة على الطفل في<br/>سن مبكرة ، تؤثر على الجوانب التنموية المختلفة. تطورها غير طبيعي. إنه<br/>يظهر خللا في تفاعله الاجتماعي ، يتميز بتكرار بعض<br/>الأنماط السلوكية والتحديات في التواصل اللفظي وغير اللفظي مع<br/>الاخرين. على مدى العقود القليلة الماضية ، أظهر انتشاره ارتفاعا كبيرا. و<br/>الملاحظة التي شجعت العديد من الباحثين في جميع أنحاء العالم على محاولة استكشاف جميع<br/>جوانبه من المسببات إلى التشخيص والتدخل. ASD هو نوع من<br/>اضطراب النمو العصبي الذي يتميز بضعف التواصل الاجتماعي و<br/>التفاعلات المتكررة ، وكذلك المصالح المحدودة.<br/>يرتبط حمض البروبيونيك (PPA) بالسلوكية والعصبية المرضية و<br/>تشوهات كيميائية حيوية لوحظت في ASD. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biochemistry |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Autism spectrum disorder |
| -- | liposomal Coenzyme Q10 |
| -- | GFAP |
| -- | CACNA1C |
| -- | BDNF |
| -- | CREB |
| -- | MeCP2 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ali El-Desouky |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ahmed Badawy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahlam Hosny Mahmoud |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mai Osman Mohamed |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2023 |
| Supervisory body | Mohamed Ali El-Desouky |
| -- | Mohamed Ahmed Badawy |
| -- | Ahlam Hosny Mahmoud |
| -- | Mai Osman Mohamed |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 13.10.2024 | 88966 | Cai01.12.02.Ph.D.2023.Do.E | 01010110088966000 | 13.10.2024 | 13.10.2024 | Thesis |