Design, synthesis and antitumor activity evaluation of some new pyrazolopyrimidine derivatives / (Record no. 170091)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04281namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033407.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250109s2024 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.19 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.05.M.Sc.2024.Ol.D. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Ola Alaa Hamed, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and antitumor activity evaluation of some new pyrazolopyrimidine derivatives / |
| Statement of responsibility, etc. | By Ola Alaa Hamed; supervisors Prof. Dr. Nehad Aboul Magd El Sayed, Dr. Walaa Ramadan Mahmoud, Dr. Ghada Fathy Elmasry. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتشييد و تقييم النشاط المضاد للاورام لبعض مشتقات البيرازولوبيريميدين الجديدة / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 199 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 176-199. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This research deals with the design and synthesis of twenty three new pyrazolo[3.4-d]pyrimidine derivatives; V, VI, VIIa,b, VIIIa,b, IXa-c, Xa.b, XI, XIIa-c, XV, XVII and XVIIIa-f as CDK2 inhibitors. Preliminary molecular modeling studies were used to support the design as well as a computational ADME study was carried out on all designed compounds. The twenty-three newly synthesized compounds were tested for their in vitro anticancer activity at the National Cancer Institute, NCI, Maryland, USA against sixty cancer cell lines. Compounds VIIa, IXc, XIIc, XVIIIa and XVIIIb displayed potent and wide range anticancer activity against almost all the cancer cell lines at the single dose screening therefore these compounds were further selected for five doses screening. Compounds VIIa, IXc, XIIc and XVIIIa were tested for their CDK2 inhibitory activity using roscovitine as a reference drug where compounds VIIa and IXc were the most potent CDK2 inhibitors and were subjected to cell cycle and apoptotic effects study. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | يتناول هذا البحث تصميم وتخليق بعض مشتقات البيرازولوبيريميدين الثلاثة و العشرون الجديدة كمثبطات لانزيمCDK2 و تم استخدام تقنيات النمذجة الجزيئية الاولية لدعم التصميم وتم إجراء دراسة ADME الحسابية على جميع المركبات المصممة. تم اختبار المركبات الثلاثة والعشرين المُصنَّعة حديثًا لمعرفة نشاطها المضاد للسرطان في المختبر في المعهد القومي للسرطان، ميريلاند، الولايات المتحدة الأمريكية علي ستين خلية. أظهرت المركبات VIIa، IXc، XIIc، XVIIIa وXVIIIb نشاطًا قويًا وواسع النطاق مضادًا للسرطان ضد جميع خطوط الخلايا السرطانية تقريبًا في فحص تركيز واحد ، لذلك تم اختيار هذه المركبات لفحص خمس جرعات أخرى. تم اختبار مشتقات VIIa IXc, XIIc, وXVIIIa لنشاطها المثبط لانزيم CDK2 باستخدام روسكوفيتين كدواء مرجعي. تم إخضاع مركبات VIIa وIXc مثبطات لاختبار تثبيط انزيم CDK2 ودراسة دورة الخلية وتأثيرات موت الخلايا المبرمج. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmaceutical Chemistry |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyrazolo[3,4-d]pyrimidine |
| -- | Anticancer activity |
| -- | Roscovitine |
| -- | Molecular docking |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nehad Aboul Magd El Sayed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walaa Ramadan Mahmoud |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghada Fathy Elmasry |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Nehad Aboul Magd El Sayed |
| -- | Walaa Ramadan Mahmoud |
| -- | Ghada Fathy Elmasry |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmaceutical Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Sara Salah |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 09.01.2025 | 89852 | Cai01.08.05.M.Sc.2024.Ol.D. | 01010110089852000 | 09.01.2025 | 09.01.2025 | Thesis |