Surgical outcome following neoadjuvant concurrent chemoradiation in breast cancer patients : (Record no. 171027)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06094namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250408120513.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250226s2024 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.99449 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.99449 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.19.04.Ph.D.2024.Kh.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Khalid Omar Omar Muhammad Alhameedy, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Surgical outcome following neoadjuvant concurrent chemoradiation in breast cancer patients : |
| Remainder of title | a single institution feasibility study / |
| Statement of responsibility, etc. | by Khalid Omar Omar Muhammad Alhameedy ; Supervision Prof. Omar Zakaria Youssef, Prof. Medhat Mohamed El Sebaie, Prof. Tamer Mostafa Manie, Prof. Ehab Mosaad Abdelghany. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | النتيجة الجراحية بعد العلاج الكيميائي والإشعاعي المتزامنين ما قبل الجراحة في مرضى سرطان الثدي : |
| Remainder of title | دراسة جدوى من معهد واحد / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 101 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 101-124. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Usually, a multimodality approach is employed in treating breast cancer in the form of systemic treatment, surgery and radiotherapy. Postoperative radiation therapy can have a detrimental effect on the breast due to local complications. In certain types of tumors, neoadjuvant radiotherapy is the standard of care. Recently, there is a trend towards utilizing such approach in breast cancer. The rationale behind neoadjuvant concurrent chemoradiation in breast cancer is that the same sequence of treatment showed excellent results in other tumor sites with improved local control and survival benefits and shorter treatment duration.<br/>Objective: To assess the surgical outcome after using concurrent chemoradiation in the neoadjuvant setting in breast cancer in terms of wound healing and postoperative complications (e.g.: seroma, infection).<br/>Methods: This is a prospective single-arm study, where eligible patients will receive neoadjuvant concurrent chemoradiation followed by surgery, and then patients will be followed-up for at least 2 months to evaluate the surgical outcome. The primary endpoint will be the rate of postoperative complications, especially skin necrosis, while the secondary endpoint will be the rate of pathological complete response (pCR) in tumors.<br/>Results: A total of 80 patients were included in the study. The total rate of postoperative complications was 10% (n=8). Only 5 patients suffered from postoperative surgical site infection, and only 3 patients (3.75%) had postoperative skin necrosis. All patients healed within 2 months postoperatively.<br/>Conclusion: This study showed that preoperative radiation therapy given concurrently with neoadjuvant systemic therapy is a safe and feasible technique with no increase in postoperative morbidity with different types of surgery and it streamlines the treatment process. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | في الآونة الأخيرة، تم استخدام العلاج الجهازي بشكل متزايد في بيئة المواد المساعدة الجديدة لسرطان الثدي وقد ثبت أن فوائد العلاج المساعد الجديد والعلاج المساعد متقاربة، مع وجود فائدة إضافية للعلاج المساعد الجديد تتمثل في زيادة الاستجابة المرضية التي تعد بديلاً لتحسين البقاء على قيد الحياة.<br/>العلاج الإشعاعي المساعد الجديد هو معيار الرعاية في بعض الأورام (مثل المريء والمستقيم) ويتم تقديمه بالتتابع مع العلاج الكيميائي المساعد الجديد كمحسس إشعاعي، مما يؤدي إلى تحسين الاستجابة المرضية وانخفاض معدلات النقائل البعيدة.<br/>وقد ثبت وجود معدل أعلى من الاستجابة الكاملة للعلاج في مرضى سرطان الثدي الذين عولجوا بالعلاج الكيميائي والإشعاعي المتزامن المساعد الجديد، ولكن لا تزال هناك شكوك حول جدوى وسلامة هذه التقنية فيما يتعلق بمعدل معدل مضاعفات ما بعد الجراحة، وخاصة نخر الجلد، بسبب التأثير السلبي للعلاج الإشعاعي على حيوية الجلد.<br/>أظهرت هذه الدراسة أن معدل مضاعفات ما بعد الجراحة بعد إعطاء العلاج الكيميائي والإشعاعي المتزامن ما قبل الجراحة لسرطان الثدي يقع ضمن الأرقام المقبولة الواردة في الأدبيات، وأنه ساعد في تبسيط جدول العلاج وتقليل الانقطاعات وعدم الامتثال، ومن ثم فهو آمن للاستخدام في مجموعة مختارة من المرضى الذين يخضعون للعلاج من سرطان الثدي. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Breast cancer |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | breast cancer |
| -- | neoadjuvant |
| -- | preoperative |
| -- | chemotherapy |
| -- | radiotherapy |
| -- | chemoradiation |
| -- | concurrent |
| -- | skin necrosis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omar Zakaria Youssef |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Medhat Mohamed El Sebaie |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tamer Mostafa Manie |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ehab Mosaad Abdelghany |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Omar Zakaria Youssef |
| -- | Medhat Mohamed El Sebaie |
| -- | Tamer Mostafa Manie |
| -- | Ehab Mosaad Abdelghany |
| Universities | Cairo University |
| Faculties | National Cancer Institute |
| Department | Department of Surgical Oncology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 26.02.2025 | 90726 | Cai01.19.04.Ph.D.2024.Kh.S | 01010110090726000 | 26.02.2025 | 26.02.2025 | Thesis |