A Pharmaceutical Study on Certain Topical Formulations of an Antifungal Drug / (Record no. 171161)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05076nam a22004337i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250317093917.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250316b2024ua |||a|||f |m|| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.4 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.4 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.08.M.Sc.2024.Em.P. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Eman Mohamed Abd-Elmonem Bedir, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | A Pharmaceutical Study on Certain Topical Formulations of an Antifungal Drug / |
| Statement of responsibility, etc. | By Eman Mohamed Abd-Elmonem Bedir; Under The Supervision of Prof. Dr. Amna Mohamad AwadAllah Makky, Assoc. Prof. Dr. Wessam Hamdy Abd El-salam, Assoc. Prof. Dr. Islam Ahmed Hamed Khalil |
| Remainder of title | Remainder of title / |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة صيدلية على تركيبات موضعية معينة لعقار مضاد للفطريات / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 96 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) -Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 76-96. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Fungal keratitis, another name for keratomycosis, is a serious and challenging condition that affects the eye and can result in irreparable vision loss or even blindness. Fungal infections in the eyes are mostly caused by the species of candida, which requires long-term usage of antifungal medication for therapy. <br/><br/>Topical eye drops are the most convenient dosage form for treating keratomycosis because they are easy to apply and have good patient compliance when compared to other ocular dose forms. However, the complex anatomy of the eye makes it difficult to achieve adequate ocular drug concentration, reducing fungal infection clearance; thus, poor ocular bioavailability, limited retention time, and low ocular tissue penetration are major concerns in the topical use of antifungal agents.<br/><br/>Amorolfine hydrochloride (AMO) is a morpholine derivative with a broad-spectrum antifungal medication that has been used to treat a variety of human fungal infections brought on by yeasts, dermatophytes, and opportunistic pathogenic fungi.<br/><br/>Mixed micelles (MMs) have been chosen as potential nanocarriers for enhancing the corneal penetration and deposition of AMO. <br/><br/>Optimum AMO-MMs showed enhanced antifungal activity with no irritation signs. AMO-MMs could be a promising alternative to the standard commercial ophthalmic suspension for fungal keratitis.<br/><br/>This study aimed to investigate and prove amorolfine HCl (AMO) antifungal activity upon drug encapsulation into a mixed micelles (MMs) vesicle system to uphold ocular penetration and drug activity. <br/><br/> |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | يعتبر الاصابة بفطريات قرنية العين ، أو التهاب القرنية الفطري ، نتيجة خطيرة محتملة يمكن أن تؤدي إلى تشوهات بصرية أو حتى العمى إذا تأخر العلاج و الناجم في اغلب الاوقات عن أنواع من الفطريات تسمي species of candida. يعد عقار الامورولفين-حمض الهيدروكلوريك (AMO)، من مشتقات المورفولين، دواء مضاد للفطريات واسع المجال يتم استخدامه لعلاج مجموعة متنوعة من الالتهابات الفطرية التي تصيب الظفر. تم اختيار المذيلات المختلطة (MMs) كمحرك نانوي محتمل لتعزيز اختراق القرنية وترسيب AMO الامورولفين-حمض الهيدروكلوريك. تم تحسين هذا النظام النانوي للتغلب على الخصائص الفيزيائية و الكيميائية للعقار(AMO) والحواجز العينية لتحقيق التتوصيل المناسب للعين. تركز هذه الدراسة على تطوير مذيلات مختلطة لتحميل الأدوية (MMs) كنظام واعد للتوصيل الموضعي الأمورولفين هيدروكلوريد (AMO-MMs) لعلاج التهاب القرنية الفطري وتحقيق إطلاق دواء مطول مع تقليل وجود العقار في الدم والذي قد يسبب بعض الاعراض الجانبية. <br/> |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmaceutical Sciences and Drug Manufacturing |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Corneal targeting |
| -- | Amorolfine HCl |
| -- | Mixed micelles |
| -- | Histopathology |
| -- | Microbiological studies, and In vivo studies |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amna Mohamad AwadAllah Makky |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wessam Hamdy Abd El-salam |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Islam Ahmed Hamed Khalil |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Amna Mohamad AwadAllah Makky |
| -- | Wessam Hamdy Abd El-salam |
| -- | Islam Ahmed Hamed Khalil |
| Universities | Cairo University |
| Faculties | Faculty of |
| Department | Department of |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Eman El gebaly |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 16.03.2025 | 90635 | Cai01.08.08.M.Sc.2024.Em.P. | 01010110090635000 | 16.03.2025 | 16.03.2025 | Thesis |