Development and validation of new analytical methods for the determination of some drugs used for the treatment of musculoskeletal disorders / (Record no. 171697)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05808namaa22004211i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250512112721.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250426s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.19 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.05.Ph.D.2024.Ay.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Ayoub Nagi Mohammed Mozayad, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Development and validation of new analytical methods for the determination of some drugs used for the treatment of musculoskeletal disorders / |
| Statement of responsibility, etc. | by Ayoub Nagi Mohammed Mozayad ; Supervision Prof. Dr. Ehab Farouk Elkady, Prof. Dr. Marwa Ahmed Fouad. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تطوير والتحقق من فاعلية بعض الطرق التحليلية الجديدة لتقدير بعض الأدوية المستخدمة لعلاج الاضطرابات العضلية الهيكلية / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 132 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 119-132. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Various analytical methods, including reversed-phase high-performance liquid <br/>chromatography (RP-HPLC) and chemometric-assisted spectrophotometry, have been developed <br/>and validated for the simultaneous determination of various drug combinations used to treat <br/>musculoskeletal disorders, particularly nonsteroidal anti-inflammatory drugs (NSAIDs) and <br/>skeletal muscle relaxants (SMRs), in laboratory-prepared mixtures and multicomponent <br/>pharmaceutical dosage forms. Also, some of these methods involved the simultaneous estimation <br/>of the selected drugs in the presence of their degradation products and main impurities with the <br/>quantitative determination of these impurities. Experimental designs, including Plackett-Burman <br/>(PBD) and Box-Behnken (BBD) designs, were used to screen and optimize the RP-HPLC <br/>parameters of the mobile phase. Furthermore, various eco-friendly multivariate calibration <br/>models and artificial neural networks (ANNs) were employed to quantify multi-component <br/>mixtures of NSAIDs and SMRs, along with their degradation products and the greenness of the <br/>suggested chemometric methods was evaluated using two distinct metrics: the analytical Eco-<br/>Scale and the analytical Greenness Calculator. The RP-HPLC methods were validated according <br/>to the International Council on Harmonization (ICH) guidelines (Q2, R1). These developed <br/>methods for routine analysis were demonstrated to be simple, sensitive, accurate, cost-effective, <br/>and highly robust. The obtained results were statistically compared to reference methods using <br/>Student's t-test and variance ratio F-test at a significance level of p < 0.05 to ensure accuracy and <br/>reliability. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | تم تطوير والتحقق من صحة طرق تحليلية متنوعة، بما في ذلك كروماتوغرافيا السائل عالية الأداء (الطور العكسي)، والتحليل الطيفي بمساعدة القياس الكيمومتري من أجل التحديد المتزامن لمجموعة متنوعة من تركيبات الأدوية المستخدمة في علاج اضطرابات الجهاز العضلي الهيكلي، خاصة الأدوية المضادة للالتهاب غير الستيرويدية (NSAIDs) ومرخيات العضلات الهيكلية (SMRs) في مخاليط محضرة في المختبر وأشكال الجرعة الصيدلانية المتعددة العناصر. كما شملت بعض هذه الطرق التقدير المتزامن للأدوية المحددة بوجود منتجات تحللها وشوائبها الرئيسية مع تحديد كمية هذه الشوائب. تم استخدام تصميمات تجريبية، بما في ذلك تصميم بلاكيت-برمان (PBD) وتصميم بوكس-بنكين (BBD) لفحص وتحسين معلمات كروماتوغرافيا السائل عالية الأداء ( الطور العكسي). علاوة على ذلك، تم استخدام نماذج المعايرة الإحصائية المتعددة وشبكات العصب الاصطناعي (ANNs) لقياس مخاليط متعددة المكونات من الأدوية المضادة للالتهاب غير الستيرويدية ومرخيات العضلات الهيكلية، بوجود منتجات تحللها وشوائبها الرئيسية. وتم إجراء التحقق من صحة طرق كروماتوغرافيا السائل عالية الأداء وفقًا للمبادئ التوجيهية التي وضعها المجلس الدولي للتنسيق (ICH). وقد ثبت أن الطرق المطورة للتحليل الروتيني بسيطة، حساسة، دقيقة، فعّالة من حيث التكلفة، ومتينة للغاية. تمت مقارنة نتائج الطرق المطورة إحصائيًا مع الطرق المرجعية لضمان الدقة والمصداقية. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmaceutical Chemistry |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | RP-HPLC |
| -- | Chemometry |
| -- | NSAIDs |
| -- | Skeletal muscle relaxants |
| -- | Plackett-Burman |
| -- | Box- Behnken designs |
| -- | ANNs |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ehab Farouk Elkady |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Ahmed Fouad |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Ehab Farouk Elkady |
| -- | Marwa Ahmed Fouad |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmaceutical Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 26.04.2025 | 90852 | Cai01.08.05.Ph.D.2024.Ay.D | 01010110090852000 | 26.04.2025 | 26.04.2025 | Thesis |