Pharmaceutical study of the photobiological and photothermal properties of sepia melanin nanoparticles / (Record no. 171881)
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|---|---|
| fixed length control field | 06082namaa22004211i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250615113020.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250504s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 621.366 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 621.366 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.24.03.Ph.D.2024.Na.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Nayera Mohamed Ali El Ghoubary, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmaceutical study of the photobiological and photothermal properties of sepia melanin nanoparticles / |
| Statement of responsibility, etc. | by Nayera Mohamed Ali El Ghoubary ; Supervisors Prof. Dr. Maha Fadel Mohamed, Prof. Doaa Ahmed Abdel Fadeel. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة صيدلانية للخواص الضوئية البيولوجية و الحرارية للجزيئات النانوية لميلانين الحبار / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 114 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 100-114. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Melanin is a natural photothermal biopolymer. It is considered the main chromophore for laser hair <br/>removal. The insolubility of melanin as an exogenous dye, in most solvents, limits its bioavailability and <br/>thus its clinical use. Melanin was extracted from a sepia ink sac and prepared as insoluble powdered sepia <br/>melanin (SM) which is identified by FTIR, 1H-NMR, thermogravimetric analysis (TGA), and scanning <br/>electron microscope (SEM). In our study, to overcome the solubility problems and increase the <br/>bioavailability of melanin for biomedical and cosmetic applications, SM was self-assembled using tween <br/>80 into dispersed nanoparticles (SM-NP-Tw). Moreover, natural sepia melanin was loaded in different <br/>delivery systems (spanlastics and transfersomes) to be delivered to the hair follicles. The prepared SM-NP-<br/>Tw were fully characterized. The photothermal performance of SM-NP-Tw was assessed. Dark and <br/>photocytotoxicity of SM-NP-Tw was studied on HepG2 cells using two wavelengths (660 nm and 820 nm). <br/>The insoluble powdered (SM) exhibited a spherical nanoparticle-like shape as revealed by scanning electron <br/>microscope and was soluble only in an alkaline aqueous solution. TGA of SM showed high resistance to <br/>thermal degradation indicating good thermal stability. The prepared SM-NP-Tw exhibited a spherical shape <br/>with mean sizes of 308±86 nm and a zeta potential of −25 mv. The cell viability decreased significantly <br/>upon increasing the concentration and upon radiation at 820 nm. The results of UV–Vis spectroscopy and <br/>the photothermal performance revealed that melanin can absorb light in a wide range of wavelengths <br/>including near the IR region; thus, it can emit sufficient heat to kill cells through the photoheat conversion <br/>effects. Melanin spanlastics and transfersomes were prepared and characterized. Transmission electron <br/>microscopy (TEM) showed the spherical shape of the prepared vesicles with average particle sizes 252 and <br/>262 nm and zeta potential of -22.5 and -35 mV for melanin spanlastics and melanin transfersomes, <br/>respectively. Histological examination of hair follicles and pilosebaceous glands for the irradiated and non-<br/>irradiated albino mice skin was studied after the application of the prepared formulations topically and <br/>subcutaneously. Qualitative statistical analysis was conducted and melanin transfersomes and melanin <br/>spanlastics showed significant damage to pilosebaceous glands and hair follicles with a p-value of 0.031 <br/>and 0.009 respectively. Sepia melanin nanoparticles self-assembled into tween-based nanostructures could <br/>be a promising natural platform for different applications including photothermal cancer therapy. As well, <br/>melanin nanoparticles loaded in transfersomes and spanlastics could be considered a promising approach <br/>for the laser removal of non-pigmented hair. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | إن الهدف من هذه الرسالة هو تحضير الميلانين في أنواع مختلفة من موصلات الدواء. الميلانين هو بوليمر حيوي حراري ويعتبر الكروموفور الرئيسي لإزالة الشعر بالليزر. و لكن عدم قابلية ذوبان الميلانين كصبغة خارجية ، في معظم المذيبات ، يعد مشكلة كبيرة تحد من توافره البيولوجي وبالتالي استخدامه اكلينيكيا. تم استخراج الميلانين من الحبار وتحضيره كمسحوق غير قابل للذوبان (SM) و تمت دراسته. ولكى نتغلب على مشاكل الذوبان وزيادة التوافر البيولوجي للميلانين ، تم تحضيره في جسيمات نانوية ، وتم تحميل الميلانين في موصلات دواء مختلفة ليتم توصيل الميلانين إلى بصيلات الشعر.تم دراسة الخواص الصيدلية للميلانين و تقييم الأداء الحراري الضوئي لها. أيضا تم دراسة سمية الميلانين على الخلايا السرطانية فى المعمل في الظلام و فى وجود الضوء باستخدام جهاز ليزربطوليين موجيين (660 نانومتر و 820 نانومتر). |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Laser Sciences |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Melanin |
| -- | melanin nanoparticles |
| -- | cancer |
| -- | laser |
| -- | hair removal |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Fadel |
| Relator term | thesis advisor. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doaa Ahmed Abdel Fadeel |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Maha Fadel Mohamed |
| -- | Doaa Ahmed Abdel Fadeel |
| Universities | Cairo University |
| Faculties | National Institute of Laser Enhanced Science |
| Department | Department of Laser Applications in Pharmaceutical Sciences |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 04.05.2025 | 91206 | Cai01.24.03.Ph.D.2024.Na.P | 01010110091206000 | 04.05.2025 | 04.05.2025 | Thesis |