A randomized clinical trial comparing perioperative blood loss after administration of preoperative intravenous tranexamic acid vs. administration of intraoperative intraarticular tranexamic acid in primary total knee arthoplasty surgery / (Record no. 172049)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 09817namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250520123000.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250512s2024 ua a|||fr|m|| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 617.471 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 617.471 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.25.M.Sc.2024.Ih.R. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Ihab Gamal Eliesh, |
| Preparation | preparation. |
| 245 12 - TITLE STATEMENT | |
| Title | A randomized clinical trial comparing perioperative blood loss after administration of preoperative intravenous tranexamic acid vs. administration of intraoperative intraarticular tranexamic acid in primary total knee arthoplasty surgery / |
| Statement of responsibility, etc. | By Ihab Gamal Eliesh; Under the supervision of Prof. DR/ Ihab Ibrahim El-Desoky, Assistant Prof. DR/Mohamed Ahmed Abd-Elmoneim, DR/ Ahmed Samir Farahat |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة مقارنة بين الحقن الموضعى والوريدى بعقار ترانكساميك اثناء عمليه مفصل الركبه الكامل الصناعى الاولى / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 100 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 65-66. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: It was revealed that systemic and local TXA treatments decreased <br/>blood loss and eliminated the need for blood transfusion following TKA without <br/>raising complication rates in this prospective comparative analysis. Blood <br/>transfusions are occasionally necessary after TKA surgery because of the high <br/>volume of blood lost during the procedure, which may range from 1450 ml to <br/>1790 ml. (4, 5, 7, 8) <br/><br/> <br/><br/>Objective: Aim of this Work was to determine the effectiveness of topical versus <br/>systemic perioperative TXA in patients undergoing total knee arthroplasty <br/>regarding: <br/>Literature reviews: The activation of the fibrinolytic system during TKA <br/>contributes to some of the blood loss that occurs. Use of tourniquets during TKA <br/>is common in order to improve visibility and assist the cementing method. <br/>Postoperative bleeding may be exacerbated by increasing the activity of the <br/>fibrinolytic system by artificial ischemia of the operated knee.(15) <br/>As a common treatment, allogeneic blood transfusion is used to boost Hb <br/>concentration, but this method has a number of dangers including volume <br/>overload and mistransfusion as well as the transfer of infections and the <br/>development of febrile responses. Allogeneic blood transfusions should be <br/>minimized in these instances. (19, 20) <br/>Different blood-conserving techniques, such as autologous blood transfusion or <br/>autologous fibrin tissue application, have been used in clinical practice to reduce <br/>the postoperative blood transfusion rates. Autologous transfusion reduces the <br/>risks of infection, but is also expensive.(14) <br/>Another method for control of the perioperative blood loss is the application of <br/>antifibrinolytic agents including TXA, TXA has attracted the most attention, there <br/>are numerous studies presenting the efficacy of TXA in reducing blood loss with <br/>no increase of complications. Several studies have identified that IV TXA is <br/>effective in reducing perioperative blood loss and blood transfusions in TKA. <br/>However, DVT after topical and IV administration of TXA is a serious complication. <br/>Therefore, many researchers have focused on the topical and IV application of <br/>TXA. However, questions still remain about the type of administration. <br/>Pa9ent and methods: 60 pa9ents with advanced arthri9s of the knee joint were <br/>surgically managed by primary TKA, in the period between February 2023 and <br/>December 2023. Pa9ents were randomized to the topical (T) or the systemic (IV) <br/>TXA intraopera9vly. The pa9ents were divided into two groups, T Group (30 <br/>pa9ents) were using topical TXA intraopera9vly, and IV group (30 pa9ents) used <br/>IV TXA. <br/>Results: The mean total blood loss in the drain a?er 24h and 48h in the T group <br/>were 300±85.1 cc and 211.67±80.60 cc respec9vely, while the mean blood loss in <br/>the drain in the IV group a?er 24h and 48h were 298.33±87.58 cc and 213.33 <br/>±74.20 cc respec9vely. In the T group, the mean preopera9ve Hb level was 11.49 <br/>g/dl, while in the IV group it was 12 g/dl , the mean 24h postopera9ve Hb in the T <br/>group was 10.39 g/dl, while in the IV group it was 10.8 g/dl), the mean 48h <br/>postopera9ve Hb in the T group was 10.14 g/dl, while in the IV group it was 10.6 <br/>g/dl. <br/>Discussion: It was revealed that systemic and local TXA treatments decreased <br/>blood loss and eliminated the need for blood transfusion following TKA without <br/>raising complication rates in this prospective comparative analysis. <br/>Conclusion: This study showed that there was no statistically significance between <br/>Topical TXA and IV TXA in reducing total blood loss, mean platelets level, mean Hb <br/>level, transfusion rate, DVTs, infection, following TKA, further studies are <br/>recommended on larger scale of patients to confirm this findings. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | مقدمة: عمليات تغيير مفصل الركبة الكامل واحده من اكثر عمليات العظام شيوعا حيث انها تخفف آلم الركبة بشكل كبير وتحسن من ممارسة المريض لحياته اليومية . وقد اظهرت تلك الجراحة نسبة فقد دم عالية تتطلب فى بعض الاحيان نقل دم تترواح كمية الدم المفقود االمسجلة فى الابحاث العلمية بين 1450 مل إلى 1790 مل. فقدان الدم الذي يحدث خلال تغيير مفصل الركبة يعود جزئيا إلى التنشيط المصاحب لنظام الفيبرين ويزيد تنشيط نظام الفيبرين استخدام العواصب بصوره كبيره. عملية نقل الدم هى النهج القياسى لزيادة نسبة الهيموجلبين وهذه الطريقة لها آثار جانبية كثيرة وتستخدم طريقة نقل الدم الذاتى التى تقلل من التعرض للعدوى لكنها طريقة مكلفة . هناك طريقة أخرى للتحكم في فقدان الدم وهي تطبيق عوامل مضادات الفيبرين . <br/>الهدف: الهدف من البحث تحديد مدى فعالية حمض الترانيكساميك الموضعى مقارنة بالوريدى للمرضى الذين يخضعون لجراحة مفصل الركبة الكامل.<br/>مراجعات الرسائل السابقة: العديد من الدراسات تقدم الفعالية الكبيرة لحمض الترانيكساميك في الحد من فقدان الدم مع عدم وجود زيادة من المضاعفات. ومع ذلك ، لا تزال هناك أسئلة حول طرق اعطائه.<br/>الطريقة: أجريت هذه الدراسة على 60 مريض يعانون من خشونة متقدمة لمفصل الركبة تم عمل تغيير مفصل كامل اولى للركبة، في الفترة ما بين فبراير 2023 وديسمبر2023. مجموعتين ، المجموعة الأولى (30 مريضا) كان بتم استخدام حمض الترانيكساميك موضعي أثناء العملية ، والمجموعة الثانية (30 مريضا) استخدم حمض الترانيكساميك الوريدى قبل الجراحة مباشرة.<br/>تم عمل الفحوصات اللازمة واجريت الجراحة وتم اخذ صورة دم كاملة اليوم الثانى للجراحة واليوم الثالث للجراحة .<br/>النتائج: أظهرت النتائج التى توصلنا اليها عدم وجود فروق ذات دلالة إحصائية بين المجموعتين فيما يتعلق مستوى الهيموجلبين والصفائح الدموية ونسبه الدم الكلى المفقود والاقامة بالمستشفى ونسبة الالتهاب ووجود جلطات وريديه عميقة. <br/>المناقشة: ومن خلال الدراسه تبين ان طريقه الحقن الموضعى لحمض الترانكساميك متساوية من حيث الفاعلية والامان بالمقارنة بطريقة الحقن الوريدى في تقليل فقد الدم ومعدل نقل الدم بعد عملية تغيبر مفصل الركبة الكامل الاولى وان حمض الترانكساميك دواء آمن مع عدم وجود زيادة في حدوث الجلطات الوريدية أو العدوى وان حمض الترانكساميك الموضعي مفيد للمرضى الذين يعانون من موانع لاستخدامه بالوريد.<br/>الخلاصة: يظهر حمض الترانجسيمك دورا فعالا فى تقليل نسبة فقد الدم بعد اجراء جراحة مفصل ركبة كامل اولى سواء تم استخدامه عن طريق الحقن الوريدى او عن الطريق الموضعى بالمفصل. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Orthopedics |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tranexamic acid |
| -- | total knee replacement |
| -- | blood transfusion |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ihab Ibrahim El-Desoky |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ahmed Abd-Elmoneim |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Samir Farahat |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Ihab Ibrahim El-Desoky |
| -- | Mohamed Ahmed Abd-Elmoneim |
| -- | Ahmed Samir Farahat |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Arthoplasty surgery |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Nourhan |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 12.05.2025 | 91111 | Cai01.11.25.M.Sc.2024.Ih.R. | 01010110091111000 | 12.05.2025 | 12.05.2025 | Thesis |