The use of β-diketone and cyanomethylene reagents for the synthesis of heterocyclic compounds and their fused derivatives with anti-tumor activities / (Record no. 172066)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03666namaa22004211i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250624110742.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250513r2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 547.59 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 547.59 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.10.Ph.D.2024.Ha.U |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Hanan Maged Labib, |
| Preparation | preparation. |
| 245 14 - TITLE STATEMENT | |
| Title | The use of β-diketone and cyanomethylene reagents for the synthesis of heterocyclic compounds and their fused derivatives with anti-tumor activities / |
| Statement of responsibility, etc. | by Hanan Maged Labib ; Supervisors Prof. Dr. Rafat Milad Mohareb, Prof. Dr. Refaat Ibrahim Naseem. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | استخدام كواشف البيتا ثنائى الكيتون وسيانوالمثيلين النشطة لتحضير مركبات غير متجانسة الحلقة ومشتاقاتها الملتحمة كمضادات للأورام النشطة / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 218 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 201-218. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In this thesis we worked on synthesizing new heterocyclic compounds using B-diketones and cyanomethylene reagents. The synthetic schemes involved multicomponent reactions. Gewald’s thiophene synthesis was also involved to produce biologically active fused thiophene compounds. Anti-proliferative evaluations and inhibitions for the new synthesized compounds and their fused derivatives towards selected cancer cell lines were carried out along with foretinib as the positive control. The results revealed that many of the new compounds have high inhibition. This opens the way for more research especially in the drugs synthesis field |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ﻓﻲ ھﺬه اﻟﺮﺳﺎﻟﺔ، ﻗﻤﻨﺎ ﺑﺘﺤﻀﯿﺮ ﻣﺮﻛﺒﺎت ﻏﯿﺮ ﻣﺘﺠﺎﻧﺴﺔ اﻟﺤﻠﻘﺔ ﺑﺎﺳﺘﺨﺪام اﻟﺒﯿﺘﺎ ﺛﻨﺎﺋﻲ اﻟﻜﯿﺘﻮن و اﻟﺴﯿﺎﻧﻮﻣﯿﺜﯿﻠﯿﻦ. ﺗﻀﻤﻨﺖ اﻟﻤﺨﻄﻄﺎت<br/>ﺗﻔﺎﻋﻼت ﻣﺘﻌﺪدة اﻟﻤﻜﻮﻧﺎت.اﯾﻀﺎ ﺗﻢ اﺳﺘﺨﺪام ﺗﻔﺎﻋﻞ Gewald’s ﻟﺘﺤﻀﯿﺮ ﻣﺮﻛﺒﺎت اﻟﺜﯿﻮﻓﯿﻦ اﻟﻨﺸﻄﺔ. ﺗﻢ ﺗﻘﯿﯿﻢ اﻟﻨﺸﺎط اﻟﻤﻀﺎد ﻟﻠﺘﻜﺎﺛﺮ<br/>و اﻟﺘﺜﺒﯿﻂ ﻟﻠﻤﺮﻛﺒﺎت اﻟﻤﺼﻨﻌﺔ ﺣﺪﯾﺜﺎ و ﻣﺸﺘﻘﺎﺗﮭﺎ ﻣﻘﺎﺑﻞ ﺧﻄﻮط اﻟﺨﻼﯾﺎ اﻟﺴﺮطﺎﻧﯿﺔ ﺟﻨﺒﺎ اﻟﻲ ﺟﻨﺐ ﻣﻊ foretinib ﻛﻌﻨﺼﺮ ﺗﺤﻜﻢ اﯾﺠﺎﺑﻲ. اظﮭﺮت اﻟﻨﺘﺎﺋﺞ ان اﻟﻤﺮﻛﺒﺎت ﻟﺪﯾﮭﺎ ﺗﺜﺒﯿﻂ ﻋﺎﻟﻲ. ھﺬا ﯾﻔﺘﺢ اﻟﻄﺮﯾﻖ ﻟﻤﺰﯾﺪ ﻣﻦ اﻟﺒﺤﺚ ﺧﺎﺻﺔ ﻓﻲ ﻣﺠﺎل ﺻﻨﺎﻋﺔ اﻟﺪواء |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Heterocyclic compounds |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | B-diketone |
| -- | Heterocyclic compounds |
| -- | cyanomethylene |
| -- | Gewald’s thiophene synthesis |
| -- | anti-tumor activity |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rafat Milad Mohareb |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Refaat Ibrahim Naseem |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Rafat Milad Mohareb |
| -- | Refaat Ibrahim Naseem |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 13.05.2025 | 91256 | Cai01.12.10.Ph.D.2024.Ha.U | 01010110091256000 | 13.05.2025 | 13.05.2025 | Thesis |