In Vitro Activity Of Colistin-Containing Antibiotic Combinations Against Colistin-Resistant Klebsiella Pneumoniae / (Record no. 172283)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03760namaa22004331a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250529112509.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250521s2024 ua a|||fr|m|| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.01 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.01 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.19.M.SC.2024.Es.I. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Esraa Kamal Mohammed Seyam, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | In Vitro Activity Of Colistin-Containing Antibiotic Combinations Against Colistin-Resistant Klebsiella Pneumoniae / |
| Statement of responsibility, etc. | By Esraa Kamal Mohammed Seyam; Supervised By Prof. Dr. Iman Ezzat Wali, Ass. Prof. Dr. Noha Mahmoud Gohar, Dr. Sabrin El-kashef. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | النشاط المختبري لمزيج الكوليستين مع مضادات حيوية أخرى ضد الكلبسيلا الرئوية المقاومة للكوليستين / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 98 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) -Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 73-98. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Multidrug-resistant (MDR) Klebsiella pneumoniae represents a growing threat to human health, causing infections associated with high morbidity and mortality. Since colistin is one of the few treatment options for treating these infections, colistin resistance represents a challenge due to the limited range of potentially available effective antibiotics. Antibiotic combination therapy has proven to be superior to monotherapy increasing the efficacy of the drugs and reducing toxicity and resistance.<br/><br/>Objectives: The study aimed to evaluate the in vitro antibacterial activity of colistin-meropenem and colistin-amikacin combinations on MDR colistin- resistant Klebsiella pneumoniae.<br/><br/>Methods: A total number of thirty colistin-resistant Klebsiella pneumoniae isolates were collected. Klebsiella pneumoniae isolates were identified by their colony morphology on MacConkey ’s agar and standard biochemical reactions. All isolates were tested for their susceptibility to antibiotics using the Kirby- Bauer disk diffusion method and proven to be multidrug -resistant. The colistin broth disk elution method confirmed colistin resistance in all isolates. The checkerboard method to test the antibiotic combinations was used.<br/><br/>Results: The results revealed that colistin-meropenem combination had a better synergistic effect (73.3%) on MDR colistin -resistant Klebsiella pneumoniae isolates compared to colistin-amikacin combination (40%) with a statistically significant difference between them (P-value= 0.015).<br/><br/>Conclusion: Antibiotic combination therapy is a promising option for treating<br/><br/>MDR colistin-resistant Klebsiella pneumoniae.<br/> |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | النشاط المختبري لمزيج الكوليستين مع مضادات حيوية أخرى ضد الكلبسيلا الرئوية المقاومة للكوليستين / |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Medical Microbiology and Immunology |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | antibiotic combination |
| -- | checkerboard |
| -- | colistin resistance |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman Ezzat Wali |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Mahmoud Gohar |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sabrin El-kashef |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Iman Ezzat Wali |
| -- | Noha Mahmoud Gohar |
| -- | Sabrin El-kashef |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Medical Microbiology and Immunology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Eman El gebaly |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 21.05.2025 | 91153 | Cai01.11.19.M.Sc.2024.Es.I. | 01010110091153000 | 21.05.2025 | 21.05.2025 | Thesis |