Synthesis, Molecular Docking Studies And Biological Evaluation Of Some Unsaturated Carbonyl Derivatives / (Record no. 172302)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04563namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250702123547.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250522s2024 ua a|||fr|m|| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 572 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 572 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.02.M.Sc.2024.Ha.S. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Hager Ahmed Sayed Ali, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis, Molecular Docking Studies And Biological Evaluation Of Some Unsaturated Carbonyl Derivatives / |
| Statement of responsibility, etc. | By Hager Ahmed Sayed; Supervisor Prof. Dr. Ismail Abdelshafy Abdelhamid, Dr .Nada Sabry Ibraheem Abd Elhady, Dr.Marwa Mohamed Mohamed Ahmed Sharaky. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التحضير ودراسات الالتحام الجزيئي والتقييم البيولوجي لبعض مشتقات الكربونيل غير المشبعة الجديدة / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 80 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) -Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 71-80. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Eight Novel chalcones were synthesized and their structures were confirmed by different spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening against several cancer cell lines. Compound 5c exerted the most promising effect against MCF7 and HEP2 cells with IC50 values of 9.5 and 12 µg/mL, respectively. Real-time PCR demonstrated the inhibitory effect of compound 5c on the expression level of Antigen kiel 67 (KI-67), Survivin, Interleukin-1beta (IL-1B), Interleukin-6 (IL-6), Cyclooxygenase-2 (COX-2) and Protein kinase B (AKT1) genes. Flow-cytometric analysis of the cell cycle indicated that compound 5c stopped the cell cycle at the G0/G1 phase in MCF7 treated cells. ELISA assay showed that Caspase 8, Caspase 9, P53, BAX, and Glutathione (GSH) were extremely activated and Matrix metalloproteinase 2 (MMP2), Matrix metalloproteinase 9 (MMP9), BCL2, Malondialdehyde (MDA), and IL-6 were deactivated in 5c treated MCF7 and HEP2 cells. Wound healing revealed that chalcone 5c reduced the ability to close the scrape wound and decreased the number of migrating MCF7 and HEP2 cells compared to the untreated cells after 48 h. Theoretical molecular modeling against P53 cancer mutant Y220C and Bcl2 showed binding energies of -22.8 and -24.2 Kcal/mole, respectively which confirmed our ELISA results. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | لقد تم تحضير ثمانية من مركبات الشالكون وتم التاكد منهم باستخدام الوسائل الطيفية المختلفه,لقد تم عمل الدراسات النظريه مثل التصميم الجزيئي لتحديد ميكانزم عمل هذه المركبات ,نتائج التاثير السمي علي الخلايا اوضحت ان المركب 5c له تاثير قوي علي الخلايا MCF7و HEP2 وقد تم اختيارهم لعمل الدراسات الجزيئيه ,لقد اوضح تحلبل البي سي ار الكمي ان المركب تسبب في نقص التعبير الجيني لجينات ki67 and survivin، IL-1B، IL-6، COX-2، AKT1 ,التحليل الفلوسيتموتري اوضح ان توقف دورة الخليه لخلايا سرطان الثدي قد تم عند مرحلة G0/G1 , وقد اوضحت نتائج تحليل الاليزا زيادة نشاطCaspase 8،Caspase 9 ، P53، BAX و GSH,وتقليل نشاط MMP2,MMP9,BCL2,MDA and IL-6 واظهر فحص التئام الجروح ان مركب 5C قلل من عدد خلايا الثدي والحنجره السرطانيه المهاجره الي مكان الجرح. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biochemistry |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chalcones |
| -- | Antioxidant |
| -- | Anti-inflammatory |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ismail Abdelshafy Abdelhamid |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nada Sabry Ibraheem Abd Elhady |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Mohamed Mohamed Ahmed Sharaky |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tayser Abdelkhalek |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Ismail Abdelshafy Abdelhamid |
| -- | Nada Sabry Ibraheem Abd Elhady |
| -- | Marwa Mohamed Mohamed Ahmed Sharaky |
| -- | Tayser Abdelkhalek |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Eman El gebaly |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 25.05.2025 | 91166 | Cai01.12.02.M.Sc.2024.Ha.S. | 01010110091166000 | 22.05.2025 | 25.05.2025 | Thesis |