Executive functions and apolipoprotein e allele 4 in cognitively normal middle-aged offspring of patients with major neurocognitive disease (Alzheimer’s Type) (Record no. 172432)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05954namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250717120238.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250531s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.831 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.831 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.21.Ph.D.2024.Yo.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Yomna Mohamed Amr Abd El-Fattah Mohamed Mattar, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Executive functions and apolipoprotein e allele 4 in cognitively normal middle-aged offspring of patients with major neurocognitive disease (Alzheimer’s Type) |
| Statement of responsibility, etc. | by Yomna Mohamed Amr Abd El-Fattah Mohamed Mattar ; Supervision Dr. Osama Refaat Ibrahim El-Sayed, Dr. Shirin Mostafa El-Makawi, Dr. Engy Medhat Ahmed, Dr. Dalia Khalifa Sayed Zayet. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الوظائف التنفيذية والأليل الرابع للأبوليبوبروتين Eلدى أبناء المرضى المصابين بأمراض عصبية معرفية عظمى (نوع الألزهايمر) ذوى وظائف ادراكية طبيعية |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 175 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 135-168. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Alzheimer's disease (AD) is a leading cause of dementia, characterized by progressive memory loss and cognitive decline, affecting millions globally. Early identification of cognitive markers in individuals at genetic risk is crucial for developing effective interventions.<br/>Objectives: This study aimed to investigate cognitive and executive functions in middle-aged offspring of patients with AD compared to healthy controls, examining the influence of the Apolipoprotein E (APOE) ε4 allele and APOE levels in plasma on these functions.<br/>Methods: This analytical observational, case-control study included 80 participants, divided into two groups: 40 offspring of AD patients (Group A) and 40 matched controls (Group B). Participants underwent comprehensive cognitive and executive function assessments, APOE genotyping, and plasma APOE level measurements.<br/>Results: The offspring group showed significantly lower performance on the Montreal Cognitive Assessment (MoCA) test, indicating early cognitive impairments despite being clinically asymptomatic. The presence of the APOE ε4 allele was higher in the offspring group, although no significant differences in plasma APOE levels were observed between the groups. A significant positive correlation was found between plasma APOE levels and cognitive performance measures.<br/>Conclusion: Middle-aged offspring of AD patients, even while cognitively normal, exhibit early cognitive vulnerabilities and a higher prevalence of the APOE4 genotype. These findings underscore the importance of early monitoring and potential interventions for individuals at genetic risk for AD. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | الوظائف التنفيذية هي مجموعة من العمليات المعرفية الضرورية للتحكم المعرفي بالسلوك عن طريق اختيار ورصد السلوكيات التي تيسر تحقيق الأهداف المطلوبة. تتضمن الوظائف التنفيذية مجموعةً من العمليات المعرفية الأساسية مثل التحكم الانتباهي والكف المعرفي والتحكم التثبيطي والذاكرة العاملة والمرونة المعرفية. تتطلب الوظائف التنفيذية العليا استخدام عدة وظائف تنفيذية أساسية في آنٍ واحد.<br/>في الآونة الأخيرة، تلقت الوظائف التنفيذية اهتمامًا متزايدًا في أبحاث مرض الألزهايمر. تعتبر اضطرابات الوظائف التنفيذية علامة مميزة لمرض الألزهايمر، حيث تظهر في وقت مبكر من مسار المرض وتنبئ بالتدهور المعرفي اللاحق. قد تعتبر العيوب الطفيفة في أداء الوظائف التنفيذية علامات مبكرة لمرض الألزهايمر لدى الأفراد الأصحاء المعرضين لخطر الإصابة بالمرض.<br/>يرتبط وجود الأليل الرابع لصميم البروتين الشحمى APOE-e4 -وهو عامل خطر جيني معروف لمرض الألزهايمر- بعيوب مبكرة في الوظائف التنفيذية لدى الأفراد غير المصابين بالخرف. وبالتالى، يمكن أن توفر دراسة تأثير APOE-e4 على أداء الوظائف التنفيذية لدى الأبناء في منتصف العمر لمرضى الألزهايمر مقارنة بأقرانهم بدون تاريخ عائلي للمرض رؤى قيمة حول التغيرات المعرفية المبكرة والعلامات المحتملة لمرض الألزهايمر. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Alzheimer’s Disease |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | مرض الزهايمر |
| 653 1# - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alzheimer's disease |
| -- | cognitive decline |
| -- | executive functions |
| -- | APOE ε4 allele |
| -- | plasma APOE levels |
| -- | genetic risk |
| -- | early detection |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Osama Refaat Ibrahim El-Sayed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shirin Mostafa El-Makawi |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Engy Medhat Ahmed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Khalifa Sayed Zayet |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Osama Refaat Ibrahim El-Sayed |
| -- | Shirin Mostafa El-Makawi |
| -- | Engy Medhat Ahmed |
| -- | Dalia Khalifa Sayed Zayet |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Psychiatry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 31.05.2025 | 91354 | Cai01.11.21.Ph.D.2024.Yo.E | 01010110091354000 | 31.05.2025 | 31.05.2025 | Thesis |