Evaluating efficacy of intravenous carbetocin versus intramyometrial injection of adrenaline in reducing blood loss during abdominal myomectomy : (Record no. 172438)
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| fixed length control field | 07409namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250531125529.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250531s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.993 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.993 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.15.M.Sc.2024.Mi.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Micheal Hany Monir Tofieles, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluating efficacy of intravenous carbetocin versus intramyometrial injection of adrenaline in reducing blood loss during abdominal myomectomy : |
| Remainder of title | a randomized controlled trial / |
| Statement of responsibility, etc. | by Micheal Hany Monir Tofieles ; Supervised Prof. Waleed Saber Abd El-Gaber, Prof. Sherif Sameh Zaki, Dr. Khaled Mohammed Hussein Kholaif. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم فعالية الكاربيتوسين في الوريد مقابل حقن الأدرينالين في عضلات الرحم في الحد من فقدان الدم أثناء استئصال الأورام الليفية الرحمية جراحيا عن طريق البطن : |
| Remainder of title | دراسة عشوائية ذات ضوابط / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 100 +(35) pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 84-100. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Uterine myomas are most prevalent benign tumors in reproductive-aged women. The management of uterine leiomyoma ranges from the expectant, conservative to definite surgery. Myomectomy is the treatment of choice for young women especially those of low parity to preserve fertility. The most common complication is high intra procedural blood loss that requires blood transfusion and hysterectomy. A number of interventions have been introduced to reduce bleeding rate during myomectomy. Carbetocin and adrenaline are used to reduce intra-operative blood loss during abdominal myomectomies.<br/>Aims of the work: to evaluate the efficacy of intravenous carbetocin versus intramyometrial injection of adrenaline in decreasing intraoperative blood loss and need for blood transfusion during abdominal myomectomy. <br/> Patients and methods: A prospective, Randomized, Comparative Clinical study was conducted in Al-kasr Al-Ainy Hospitals – Cairo University during the period from May 2023 to April 2024. This study was carried out on 62 women with symptomatic uterine fibroids aged 25-50 years old. The study population was divided into 2 groups: Group A (Cabetocin group): Includes 31 patients received after the induction of anesthesia, 100 mcg IV carbetocin in 10 mL saline solution administrated slowly over 5 minutes (at a rate of 2 mL/min). Group B (Adrenaline group): Includes 31 patients who had infiltration of the serosa and/or myometrium overlying the leiomyoma before uterine incision with a solution composed of 50 ml Bupivacaine HCL 0.25% and 0.5 mg of adrenaline. The solution was prepared just before the procedure.<br/> Results: Intra-operative blood loss was significantly lower in those women randomized to receive intramyometrial infiltration of adrenaline versus the carbetocin group (373.29 ml versus 742.81ml). Additionally, there was a highly significant statistical difference between Adrenaline group and Carbetocin group as regards the postoperative hemoglobin, hematocrit concentration and operative time (P<0.001) as Adrenaline group showed a higher postoperative hemoglobin and hematocrit concentration, and less operative time . There was no statistical significant difference between both groups as regards the blood transfusion. In addition, we found that there was significant difference as regards side effects as nausea and vomiting in carbetocin group, tachycardia, and hypertension in adrenaline group.<br/> Conclusion: Intramyometrial injection of a solution of bupivacaine (50 ml of 0.25%) plus adrenaline (0.5 ml of 1 mg/ml) is very effective in reducing intraoperative bleeding during abdominal myomectomy. This solution is significantly more effective than intravenous infusion of carbetocin. However, it offers no additional benefits over carbetocin regarding the need for blood transfusion. In addition, adrenaline shows side effects regarding tachycardia and hypertension. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | تعتبر الأورام الليفية بالرحم من الأورام الحميدة . وهي أكثر أورام الحوض شيوعا لدى النساء وتمثل مشكلة شائعة بين السيدات في سن الانجاب. وتظل الجراحة هي الطريقة الرئيسية لعلاج الأورام الليفية الرحمية، وتعد عملية استئصال الورم الليفي هي الخيار الأفضل بالنسبة للنساء اللواتي تعانين من اورام ليفية بالرحم ولم يكملن الانجاب ومن يريدن الحفاظ على الخصوبة. ويعتبر النزيف أثناء العملية هو الخطر الجراحي الأكبر، مما يجعل الجراحة أكثر خطورة وقد تؤدي إلى استئصال الرحم كما يمكن أن تؤدي إلى صدمة نقص حجم الدم أثناء العملية وينتج عنه فقر الدم بعد العملية. لذلك يتم استخدام العديد من التقنيات لتقليل فقدان الدم أثناء استئصال الورم الليفي بما في ذلك، منبهات GnRH قبل الجراحة، والعاصبة والمشابك الميكانيية الجراحية المحيطة بعنق الرحم أثناء العملية، وحقن عقار الفاسوبريسين أو مقبضات الاوعية داخل عضلة الرحم وربط الشريان الرحمي ومقبضات الرحم ( الميزوبروستول ، الكاربيتوسين ،وما الى ذلك..)<br/>يرتبط الكاربيتوسين، الذي يعد أوكتاببتيدًا تركيبيًا، بانتقائية بمستقبلات الأوكسيتوسين في عضلات الرحم، مما يسبب انقباضات منتظمة وزيادة في توتر الرحم. يمكن إعطاء الكاربيتوسين عن طريق الحقن كجرعة واحدة، إما عن طريق الوريد أو عضليًا.<br/>يستخدم الأدرينالين، وهو قابض قوي للأوعية الدموية، بشكل رئيسي لتقليل فقدان الدم خلال العمليات الجراحية في النساء، وعمليات الاستئصال التي تتم عن طريق المنظار، والإجراءات الجلدية.\ |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Benign tumors |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | carbetocin |
| -- | adrenaline |
| -- | bupivacaine |
| -- | blood loss |
| -- | abdominal myomectomy |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Waleed Saber Abd El-Gaber |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherif Sameh Zaki |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khaled Mohammed Hussein Kholaif |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Waleed Saber Abd El-Gaber |
| -- | Sherif Sameh Zaki |
| -- | Khaled Mohammed Hussein Kholaif |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Obstetrics and Gynecology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 31.05.2025 | 91357 | Cai01.11.15.M.Sc.2024.Mi.E | 01010110091357000 | 31.05.2025 | 31.05.2025 | Thesis |