Assessment of M1 and M2 macrophages in chronic myeloid leukemia patients / (Record no. 172664)
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| fixed length control field | 06404namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250805120130.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250621s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.99419 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.99419 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.07.Ph.D.2024.Ya.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Yasmine Rabie Hashem Youssef Elammary, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of M1 and M2 macrophages in chronic myeloid leukemia patients / |
| Statement of responsibility, etc. | by Yasmine Rabie Hashem Youssef Elammary ; Supervision Prof. Dr. Iman Maher Mansour, Prof. Dr. Somaia Mohamed Abdelrahman Mousa, Prof. Dr. Hanan Al-Husseini Al-Wakeel,Prof. Dr. Maha Farouk Youssef Yacoub. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة خلايا البلاعم M1 و M2 فى مرضى سرطان الدم النخاعى المزمن |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 122 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 106-122. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: CML is a clonal malignancy characterized by chromosomal translocation and the fusion of the BCR and ABL1 genes. The bone marrow microenvironment comprises versatile cells and is considered a shelter to the LSCs. Tumor-associated macrophages (TAMs) are considered as a crucial component of the tumor microenvironment and macrophage polarization may have a role in CML pathogenesis.<br/> Aim: The study aims at evaluating macrophage polarization in CML patients through the assessment of the expression of CD68, P-STAT1- positive M1 macrophages and CD206- positive M2 macrophages in the bone marrow biopsies of these patients. This intends to determine whether the change in macrophage phenotype in CML patients is towards M1 or M2 phenotype. In addition to the evaluation of the association of these markers with the laboratory profiles and treatment outcome in these patients, according to molecular response.<br/>Methods: The study comprised 30 newly diagnosed CML patients. Twenty age and sex matched patients with hypersplenism and Immune thrombocytopenic Purpura (ITP) were included in the current study as a control group. Immunohistochemistry (IHC) technique was performed for the study of CD68, Phospho-STAT1 and CD206.<br/><br/>Results: In the present work, CML patients had higher median M2%/HPF (P-value<0.001) and higher median M2/M1 ratio (p-value=0.009) than control group. As regards the laboratory data in these patients, a positive correlation was observed between BCR-ABL1% at diagnosis and M2%/HPF (p-value=0.027, r=0.402).<br/>Conclusion: From these results we can conclude that macrophage polarization in CML patients is towards the M2 phenotype and that different M1 and M2 macrophage subsets may correlate to some clinical and laboratory data in these patients. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | سرطان الدم النخاعي المزمن هو ورم خبيث يتميز بانتقال بين الكروموسومات واندماج جينات BCR وABL1. تشتمل البيئة الدقيقة لنخاع العظم على خلايا متعددة وتعتبرمأوى للخلايا الجذعية السرطانية. تعتبرخلايا البلاعم المرتبطة بالورم (TAMs) عنصرًا حاسمًا في البيئة الدقيقة للورم وقد يكون لاستقطاب البلاعم دور في التسبب في سرطان الدم النخاعي المزمن.<br/> تهدف الدراسة إلى تقييم استقطاب خلايا البلاعم لدى مرضى سرطان الدم النخاعي المزمن من خلال تقييم التعبير عن البلاعم CD68، والبلاعم M1 الإيجابية لـ P-STAT1 مع CD68، والبلاعم M2 الإيجابية CD206 في خزعات نخاع العظم لهؤلاء المرضى. يهدف هذا إلى تحديد ما إذا كان التغيير في النمط الظاهري للبلاعم لدى مرضى CML يتجه نحو النمط الظاهري M1 أو M2. بالإضافة إلى تقييم ارتباط هذه العلامات بالملامح المختبرية ونتائج العلاج لدى هؤلاء المرضى حسب الاستجابة الجزيئية.<br/> شملت الدراسة 30 مريضاً تم تشخيصهم حديثاً بسرطان الدم النخاعي المزمن. كما شملت عشرين مريضا يعانون من فرط نشاط الطحال أو نقص الصفائح الدموية المناعية (ITP) في الدراسة الحالية كمجموعة مراقبة. تم إجراء تقنية الكيمياء المناعية (IHC) لدراسة CD68، Phospho-STAT1 CD206<br/>اظهرت النتائج في هذه الدراسه أن متوسط M2%/HPF في مرضى سرطان الدم النخاعي المزمن أعلى (قيمة P <0.001) ومتوسط نسبة M2/M1 أعلى (قيمة P = 0.009) مقارنة بالمجموعة الضابطة. فيما يتعلق بالبيانات المختبرية لدى هؤلاء المرضى، لوحظ وجود علاقة إيجابية بين BCR-ABL1% عند التشخيص وM2%/HPF (قيمة p=0.027، r=0.402..)<br/> من هذه النتائج يمكننا أن نستنتج أن استقطاب البلاعم في مرضى سرطان الدم النخاعي المزمن يتجه نحو النمط الظاهري M2 وأن نسبة M2 قد ترتبط ببعض البيانات السريرية والمختبرية لدى هؤلاء المرضى. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Leukemia |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | leukemia |
| -- | M1 and M2 |
| -- | macrophages in chronic |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman Maher Mansour |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Somaia Mohamed Abdelrahman Mousa |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Al-Husseini Al-Wakeel |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Farouk Youssef Yacoub |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Iman Maher Mansour |
| -- | Somaia Mohamed Abdelrahman Mousa |
| -- | Hanan Al-Husseini Al-Wakeel |
| -- | Maha Farouk Youssef Yacoub |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Clinical and Chemical Pathology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 21.06.2025 | 91676 | Cai01.11.07.Ph.D.2024.Ya.A | 01010110091676000 | 21.06.2025 | 21.06.2025 | Thesis |