Clinicopathological studies on some novel renal biomarkers in cats / (Record no. 172712)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 05095namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250807115326.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250623s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 636.8 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 636.8 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.10.05.Ph.D.2024.Gh.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Ghada Mohamed Mohamed Ahmed Khalil, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Clinicopathological studies on some novel renal biomarkers in cats / |
| Statement of responsibility, etc. | by Ghada Mohamed Mohamed Ahmed Khalil ; Supervised Prof. Dr. Safaa Y. S. Ahmed, Prof. Dr. Shaymaa I. Salem, Prof. Dr. Khaled M. A. Mahran, Dr. Mohamed E. Ali. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسات باثولوجية إكلينيكو لبعض دلالات الكلى الحيوية الحديثة في القطط |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 98 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 74-97. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Renal diseases are common disorders of felines, considered a leading death <br/>cause, and exhibit a diagnostic challenge due to a shortage of early damage markers. <br/>The traditional biomarkers [e.g., serum creatinine (sCr) and blood urea nitrogen (BUN)] <br/>have low diagnostic sensitivity; thus, acute cases progress to chronic. This study aimed <br/>to clarify the clinicopathological, ultrasonographic, and pathological findings of cats <br/>affected with renal diseases, and the performance of novel renal biomarkers [symmetric <br/>dimethyl arginine (SDMA), kidney injury molecule-1 (KIM-1), Tamm-Horsfall protein <br/>(THP), and N-acetyl-β-D-glucosaminidase (NAG)] against the traditional ones. <br/>Furthermore, assessing the novel biomarker‟s role in the follow-up of treated cases. 86 <br/>cats were allocated into 4 groups depending on clinical signs, physical examination, sCr <br/>concentration, and urine specific gravity (USG) as follows: I. Control negative group <br/>(15 apparently healthy cats), II. Control positive group (22 renal diseased cats), III. Pre-<br/>azotemic group (31 cats), and IV. Diseased and treated group (18 treated cats). Blood <br/>and spot urine samples were collected from all groups. Blood samples for <br/>hematological, biochemical, arterial blood gas (ABG) analysis, as well as, SDMA, and <br/>KIM-1 concentrations. Spot urine samples for routine urinalysis, some biochemical <br/>parameters, NAG activity, and THP concentration. Groups II and III showed microcytic <br/>hypochromic anemia and significant leukopenia, significant increases in serum <br/>concentrations of SDMA, and KIM-1, and activity of urinary NAG; meanwhile, they <br/>showed a significant decrease in urinary THP concentration. Group IV after treatment <br/>revealed an improvement of all measured parameters except urinary THP concentration. <br/>In conclusion, the current study results found out that SDMA, KIM-1, and NAG could <br/>serve as efficient biomarkers of early renal injury detection and treatment follow-up. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | تعتبر أمراض الكلى من أكثر المشكلات الطبية شيوعًا في القطط والتي تسبب خلل فسيولوجي وأيضي. العديد من الأسباب الفسيولوجية المرضية قد تتسبب في إحداثها من بينها الإصابة الحادة للكلي بالتلف والذي بدوره يؤدي إلى إنحدار سريع في وظائف الكلى وقد ينتهي بفشل مزمن في وظائف الكلى. يعنبر القط الحيوان الأكثر إصابة ووفاة من أمراض الكلى المزمنة من أي حيوان آخر خاصة القطط الكبيرة في السن بنسبة حدوث 80 %. <br/>الدلالات الحيوية هي جزيئات حيوية، غالبًا ما تكون بروتينات، تتأرجح (زيادة أو نقصان) نتيجة التغيرات المرضية. بدأ عصر جديد في مجال طب وأمراض الكلى مع ظهور الدلالات الحيوية الجديدة الخاصة بتلف الكلى، كما أنها طورت أولوية بحثية ترتبط بتحسين التشخيص والمتابعة والتكهن وصنع القرارات والأدوات الجديدة الخاصة بأمراض الكلى. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cats |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SDMA |
| -- | urinalysis |
| -- | THP |
| -- | NAG |
| -- | KIM-1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Safaa Y. S. Ahmed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shaymaa I. Salem |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khaled M. A. Mahran |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed E. Ali |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Safaa Y. S. Ahmed |
| -- | Shaymaa I. Salem |
| -- | Khaled M. A. Mahran |
| -- | Mohamed E. Ali |
| Universities | Cairo University |
| Faculties | Faculty of Veterinary Medicine |
| Department | Department of Clinical Pathology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 23.06.2025 | 91687 | Cai01.10.05.Ph.D.2024.Gh.C | 01010110091687000 | 23.06.2025 | 23.06.2025 | Thesis |