S100A4 gene polymorphism in type 2 diabetic patients and its relation to diabetic complications (Record no. 173109)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06302namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250819130220.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250719s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.466 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.466 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.18.Ph.D.2024.He.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Heba Abdallah Yossef Emam Nada, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | S100A4 gene polymorphism in type 2 diabetic patients and its relation to diabetic complications |
| Statement of responsibility, etc. | by Heba Abdallah Yossef Emam Nada ; Supervised Prof. Dr. Heba Sherif Kareem, Prof. Dr. Heba Sayed Abdelaziz Assal, Dr. Samaa Ayman Anwar,Dr. Doaa Mohamed Abdo. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تعدد الشكل الجيني ل س 100أ4 فى مرضى السكري من النوع الثاني وعلاقتها بمضاعفات السكري |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 232 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 193-232. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Diabetes mellitus is a serious metabolic disorder in which microvascular complications, <br/>such as peripheral neuropathy, retinopathy, and nephropathy, regularly occur but may remain <br/>undetected in daily practice. S100A4 has recently been reported as a novel biomarker and an important <br/>regulator of glioma stem cells, with its increased expression contributing to the appearance of a <br/>metastatic phenotype, as well as having been described as a marker for lupus nephritis activity, a <br/>determinant factor for the onset of the complex inflammatory autoimmune disease lupus <br/>erythematosus; Aim of work: Our study aimed to assess the potential value of S100A4 gene <br/>polymorphism as a diagnostic biomarker of nephropathy in type 2 diabetic patients and to assess <br/>the association between S100A4 gene polymorphism and carotid intima media thickness; Patients <br/>and Methods: This is observational case-control study included 150 patients with type 2 diabetes <br/>and 50 age- and sex-matched healthy controls, aged 40 to 70 classified into four groups: Group I: <br/>50 diabetic patients no albuminuria. Group II: 50 diabetic patients with microalbuminuria. Group <br/>III: 50 diabetic patients with macroalbuminuria. Group IV: 50 healthy controls; Results: No <br/>significant differences in gender and age among the groups. However, BMI, DM duration, and <br/>blood pressure were significantly higher in diabetic groups, especially in patients with <br/>macroalbuminuria. Fasting blood sugar, 2-hour postprandial sugar, and HbA1c levels were <br/>significantly elevated in diabetic groups. Serum creatinine and urea levels also showed significant <br/>differences, indicating renal involvement in diabetes progression. The study found a significant <br/>correlation between S100A4 levels and the severity of albuminuria in diabetic patients, <br/>highlighting its potential as a biomarker; Conclusion: The study examined 150 type 2 diabetes <br/>mellitus (T2DM) patients and 50 controls, revealing significant differences in clinical, laboratory, <br/>and genotypic parameters. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | مرض السكري هو اضطراب ايضى خطير تحدث فيه مضاعفات الأوعية الدموية الدقيقة، مثل الاعتلال العصبي المحيطي واعتلال الشبكية واعتلال الكلي، ولكنها قد تظل غير مكتشفة في الممارسة اليومية.<br/>اعتلال الكلي السكري هو أكثر أمراض الكلى المزمنة انتشارًا وهو السبب الرئيسي لأمراض الكلى في المرحلة النهائية في جميع أنحاء العالم. ويرجع ذلك في الغالب إلى تزايد الإصابة بمرض السكري من النوع الثانى المرتبط بالسمنة.<br/> مثل أمراض الكلى المزمنة الأخرى، يتم تصنيف التطور لاعتلال الكلي السكري وفقًا لمستوى إفراز ألبومين البول وانخفاض معدل الترشيح الكبيبي.<br/>في مرضى السكري، يوصف تطور الزلال الدقيق فى البول بأنه اعتلال الكلي الأولي، في حين أن وجود الزلال الكبير في البول يوصف بأنه اعتلال الكلي العلني، ويعتبر معدل الترشيح الكبيبي أقل من 15 مل/دقيقة/1.73 م2 فشل كلوى والجدير بالذكر أن الإصابة الكلوية تتقدم في حوالي ثلث المرضى الذين يعانون من اعتلال الكلي السكري ويمكن أن يعاني بعض المرضى من زلال البول الدقيق أو اعتلال الكلي العلني أو كلاهما معا الذي يرتبط عادة بتحسين السيطرة على مرض السكري وارتفاع ضغط الدم مع الأدوية.<br/>بالنسبة لدور الالتهاب في اعتلال الكلي السكري سابقًا في سياق النظريات الحالية التي تركز على الالتهاب وتنشيط الأرومة الليفية مثل الانتقال الظهاري إلى الوسيط والانتقال البطاني إلى الوسيط .<br/>إن سمك الوسائط الداخلية للشريان السباتي المشترك هو مؤشر قابل للقياس لوجود بعض التشوهات. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Diabetes |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | S100A4 Gene Polymorphism |
| -- | Type 2 Diabetic Patients |
| -- | Diabetic Complications |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Sherif Kareem |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Sayed Abdelaziz Assal |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samaa Ayman Anwar |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doaa Mohamed Abdo |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Heba Sherif Kar |
| -- | Heba Sayed Abdelaziz Assal |
| -- | Samaa Ayman Anwar |
| -- | Doaa Mohamed Abdo |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Internal Medicine |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 19.07.2025 | 91798 | Cai01.11.18.Ph.D.2024.He.S | 01010110091798000 | 19.07.2025 | 19.07.2025 | Thesis |