MARC details
| 000 -LEADER |
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| fixed length control field |
06662namaa22004211i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - أخر تعامل مع التسجيلة |
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| control field |
20250814101440.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250811s2024 ua a|||fr|m|| 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloguing agency |
EG-GICUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GICUC |
| Modifying agency |
EG-GICUC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract |
eng |
| -- |
ara |
| 049 ## - Acquisition Source |
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| Acquisition Source |
Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
612.1121 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) |
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| Classification number |
612.1121 |
| Edition number |
21 |
| 097 ## - Degree |
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| Degree |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Local Call Number |
Cai01.07.04.M.Sc.2024.Mo.C. |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Authority record control number or standard number |
Mohga Magdy Said Ghareeb, |
| Preparation |
preparation. |
| 245 10 - TITLE STATEMENT |
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| Title |
Cancer Treatment by Some Natural Plant Extracts / |
| Statement of responsibility, etc. |
By Mohga Magdy Said Ghareeb; Under the Supervision of Dr. Ahmed Mahmoud Mostafa Aboul-enein, Dr. Amr Abdelmotagaly Nassrallah |
| 246 15 - VARYING FORM OF TITLE |
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| Title proper/short title |
علاج بعض الامراض السرطانيه باستخدام المستخلصات النباتيه الفعاله |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Date of production, publication, distribution, manufacture, or copyright notice |
2024. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
141 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
25 cm. + |
| Accompanying material |
CD. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Source |
rda content |
| 337 ## - MEDIA TYPE |
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| Media type term |
Unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
volume |
| Source |
rdacarrier |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliography: pages 105-141. |
| 520 #3 - SUMMARY, ETC. |
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| Summary, etc. |
In recent decades, researchers have become interested in alternative cancer <br/>treatments. Plants are naturally loaded with a variety of phytochemicals. These <br/>chemicals, which belong to various chemical classes, contain a number of secondary <br/>metabolites. In this work, ethanol 80% was used to extract the different parts of five <br/>wild plants from Egypt: moringa leaves (Moringa oleifera), vinca leaves (Vinca rose), <br/>fennel seeds (Foeniculum vulgare), chicory leaves (Cichorium intybus), and cresson <br/>seeds (Lepidium sativum). The plant extracts were examined for biological activity. <br/>Strong antioxidant and anticancer properties were demonstrated by the extracts. DPPH <br/>and reducing power assays were used to evaluate the antioxidants. The ethanol extracts <br/>revealed potential antioxidants with corresponding IC values of 55.35, 185.05, 87.66, <br/><br/>50<br/>7.89 and 167.57µg/mL. The current findings demonstrated that vinca extract had strong <br/>anticancer properties against colorectal (Caco-2) cell line, with an IC of 11.7 µg/mL, <br/><br/>50<br/>while moringa, fennel, cresson, and chicory had weaker anticancer effects, with IC of <br/><br/>50<br/>25.32, 11.9, 26.7, and 52.86 µg/mL, respectively. the contents of total phenols (TPC) <br/>and flavonoids (TFC) were assessed and fractionated, and the analysis revealed that <br/>TPC and TFC were virtually the same in five ethanol plant extracts. TPC and TFC were <br/>represented as mg gallic acid equivalent/gm sample (D.W) and mg quercitin <br/>equivalent/gm sample (D.W), respectively. The biological activity indicated above may <br/>be caused by these substances. For this reason, the gene expression of important pro- <br/>and anti-apoptosis indicators were examined in Caco2 cells exposed to IC , which was <br/><br/>50<br/>used to assess the induction of apoptosis in Moringa oleifera and Vinca rosa. the gene <br/>expression of various signal transduction key markers controlling apoptosis process was <br/>tested, such as p53, Bax, caspase-3 and Bcl-2 key markers. The RTqPCR-results showed <br/>that Moringa have potential apoptosis induction compared to vinca and respective <br/>control. The data obtained in the present study suggests that extracts would be useful as <br/>pharmaceutical material to treat cancer separately or with combine other chemical to <br/>enhance the anticancer effects, our results also suggest that inclusion of antioxidant and <br/>anticancer-rich extract of V. rosea, M. oleifera or L. sativum as dietary supplementaries <br/>have beneficial effects for human health |
| 520 #3 - SUMMARY, ETC. |
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| Summary, etc. |
في هذه الدراسة استخدمنا الإيثانول بنسبة 80٪ لإنتاج خمس مستخلصات نباتيه من نباتات مصرية برية: (المورينجا، الونكا، الشمر، حب الرشاد والشكوريا) قمنا بعد ذلك بفحص الاجزاء النباتية المختلفة بحثًا عن النشاط البيولوجي. أظهرت المستخلصات خصائص قوية مضادة للأكسدة ومضادة للسرطان. تم استخدام طريقه ال DPPH وطريقة قدره اﻹختزال (reducing power) بتركيزات مختلفة.كشفت مستخلصات الإيثانول عن مضادات أكسدة بقيم IC50 (55.35 و185.05 و87.66 و167.57 و7.89 ميكروجرام / مل). كما أظهرت النتائج الحالية أن مستخلص الونكا له خصائص قوية مضادة للسرطان ضد أورام القولون والمستقيم (Caco-2)، بتركيز IC50 يبلغ (11.7 ميكروجرام / مل)، في حين أن المورينجا والشمر وحب الرشاد والشكوريا لها تأثير مضاد للسرطان أضعف بتركيز IC50 (11.9-25,32-26,7-و52,86 ميكروجرام/مل) على التوالي. و باستخدام تقنية HPLC تم تقدير نسبه الفينولات (TP) والفلافونيدات (TF). وكشف التحليل أن TP وTF كانت متماثلة تقريبًا في الخمس مستخلصات نباتية من الإيثانول. تم تمثيل TP وTF كعينة مجم من مكافئ كيرسيتين / جم من الوزن الجاف للعينه ومجم مكافئ حمض الجاليك / جم من الوزن الجاف للعينه ، على التوالي. قد يكون النشاط البيولوجي المشار إليه أعلاه بسبب هذه المواد، لهذا السبب قمنا بفحص التعبير الجيني لل pro and anti-apoptotic gene لخلايا Caco2 والتي تتحكم في عملية موت الخلايا المبرمج وذلك باستخدام مستخلصات كلا من المورينجا والونكا. اختبرنا التعبير الجيني للعديد من الجينات مثل p53) وBax وcaspase-3 وBcl-2). أظهرت نتائج RTqPCR أن المورينجا لها تأثير أكبر علي موت الخلايا المبرمج مقارنة بالونكا |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Issues CD |
Issued also as CD |
| 546 ## - LANGUAGE NOTE |
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| Text Language |
Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Biochemistry |
| 653 #1 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Anti-Cancer |
| -- |
Anti-Oxidant |
| -- |
Caco-2 cell line |
| -- |
Cichorium intybus |
| -- |
Lepidium sativum |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ahmed Mahmoud Mostafa Aboul-enein |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Amr Abdelmotagaly Nassrallah |
| Relator term |
thesis advisor. |
| 900 ## - Thesis Information |
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| Grant date |
01-01-2024 |
| Supervisory body |
Ahmed Mahmoud Mostafa Aboul-enein |
| -- |
Amr Abdelmotagaly Nassrallah |
| Universities |
Cairo University |
| Faculties |
Faculty of Agriculture |
| Department |
Department of Biochemistry |
| 905 ## - Cataloger and Reviser Names |
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| Cataloger Name |
Nourhan |
| Reviser Names |
Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
| Edition |
21 |
| Suppress in OPAC |
No |