Design and synthesis of novel heterocyclic compounds derived from 1,3-diketones and evaluation of their cytotoxicity / (Record no. 173940)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04677namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250929122823.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250909s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 547 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 547 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.10.Ph.D.2025.Ib.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Ibram Refat Boshra Mikhail, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Design and synthesis of novel heterocyclic compounds derived from 1,3-diketones and evaluation of their cytotoxicity / |
| Statement of responsibility, etc. | by Ibram Refat Boshra Mikhail ; Supervisors Prof. Dr. Rafat Milad Mohareb , Prof. Dr. Refaat Ibrahim Neseem. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتحضير مركبات جديدة غير متجانسة الحلقة مشتقة من مركبات ١,٣ - ثنائى الكيتون وتقييم سميتها الخلوية |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 252 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 235-252. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Throughout this work, novel heterocyclic compounds were synthesized as potent anticancer agents. β-Dicarbonyl compounds served as key building blocks in multicomponent reactions with other reagents to produce a diverse spectrum of novel heterocyclic compounds derived from quinolines, isoquinolines, chromenes, indazole, pyran, pyarzole, and thiophene. The synthesized compounds were obtained and characterized using various spectroscopic techniques. The antiproliferative activities of the newly synthesized compounds were evaluated against the six cancer cell lines: A549, HT-29, MKN-45, U87MG, SMMC-7721, and H460. The activities of the new synthesized compounds were compared to Foretinib as the positive control by MTT assay. Results revealed that many of these new compounds have high inhibitory effect on cell proliferation. All tested compounds displayed potent c-Met enzymatic activity with IC50 values ranging from 0.25 to 10.30 nM and potent prostate PC-3 cell line inhibition with IC50 values ranging from 0.17 to 9.31 μM. This finding suggests valuable insights for the development of new anticancer drugs |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | هذا العمل يركز على تحضير مركبات حلقية جديدة غير متجانسة الحلقة كعوامل محتملة مضادة للسرطان. تفاعلت مركبات البيتا ثنائى الكاربونيل ،كوحدات بناء رئيسية، مع مركبات اخرى ، خلال تفاعلات متعددة المكونات، مما سمح بإنشاء العديد من المركبات الجديدة غير متجانسة الحلقة المشتقة من الكينولين والايزوكينولين والكرومين و الاندازول واليران والبيرازول والثيوفين . تم عزل المركبات المصنعة وتحليلها باستخدام تقنيات مختلفقة ، ثم تم تقييمها مع ستة خطوط خلوية سرطانية وهم A549 و HT-29 و MKN-45 و U87MG و SMMC-7721 و H460 . <br/>تم مقارنة نشاط هذه المركبات الجديدة مع Foretinib كعنصر تحكم ايجابى بواسطة اختبار MTT حيث كشفت النتائج ان العديد من هذه المركبات الجديدة لها تأثير مثبط قوي على انتشار الخلايا السرطانية. فقد اظهرت جميع المركبات المختبرة نشاطا انزيميا قويا ل c-Met بقيم IC50 تتراوح من 0.25nM الى 10.30nM بالإضافة إلى تثبيط قوى لخط الخلية السرطانية البروستاتي PC-3 بقيم IC50 تتراوح من من 0.17nM الى 9.31nM . هذه النتائج الجيدة تفتح الافق لتطوير ادوية جديدة مضادة للسرطان. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Organic Chemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الكيمياء العضوية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Quinolins |
| -- | isoquinolines |
| -- | Chromenes |
| -- | indazole |
| -- | pyran |
| -- | pyrazole |
| -- | 1,3-diones |
| -- | thiophene |
| -- | thieno-[3, 2-e]indazole |
| -- | Cytotoxicity |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rafat Milad Mohareb |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Refaat Ibrahim Naseem |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Rafat Milad Mohareb |
| -- | Refaat Ibrahim Naseem |
| Universities | Cairo University |
| Faculties | Faculty of Chemistry |
| Department | Department of Organic Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 09.09.2025 | 91995 | Cai01.12.10.Ph.D.2025.Ib.D | 01010110091995000 | 09.09.2025 | 09.09.2025 | Thesis |