Application of advanced analytical techniques for quality assessment of selected drugs contain amino group / (Record no. 173947)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05258namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250929123822.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250909s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.19 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.03.M.Sc.2025.Ma.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mai Mohamed Talaat Ahmed, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Application of advanced analytical techniques for quality assessment of selected drugs contain amino group / |
| Statement of responsibility, etc. | by Mai Mohamed Talaat Ahmed ; Supervision Prof. Dr. Hala Elsayed Zaazaa, Prof. Dr.Nahla Sayed Ismail Asst. Prof. Dr.Shereen Ahmed Boltia. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تطبيق تقنيات تحليلية متقدمة لتقييم جودة أدوية مختارة تحتوي على المجموعة الأمينية |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 54 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 12-14. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | This thesis focuses on the quantitative analysis of certain drugs containing an amino group, such as Teriflunomide and Dorzolamide HCl, whether alone or in combination with Timolol Maleate, respectively. The objective of this research was to develop reliable, rapid, simple, sensitive, precise, and robust methods for determining the analytes with high accuracy and precision. These methods are intended for routine analysis in both bulk and pharmaceutical dosage forms.<br/><br/>Two rapid, accurate, precise, and sensitive stability-indicating high-performance chromatographic methods were developed and validated for estimating Teriflunomide in the presence of its degradation products. The structures of the degradation products were elucidated using LC-MS. Additionally, two simple UV spectrophotometric methods were employed to determine Teriflunomide in the presence of its degradation products (pharmacopeial impurities). The first method involved measuring absorbance spectra from 200 to 400 nm, using one of the impurities as a divisor, followed by constructing the first derivative curve of the ratio spectrum. The second method was the dual wavelength method for the drug ratio spectra.<br/>Three innovative carbon paste electrodes were constructed to measure Dorzolamide HCl in both its active pharmaceutical ingredient (API) form and in pharmaceutical preparations containing Timolol Maleate. These included a conventional carbon paste electrode (I), a modified carbon paste electrode incorporating Silica (II), and another modified carbon paste electrode incorporating β-cyclodextrin (III). This research is based on the interaction between Dorzolamide HCl and phosphomolybdic acid to form an electroactive dorzolamide-phosphomolybdate ion exchanger, with dibutylphthalate used as a solvent mediator. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | ﺗﺘﻨﺎول ھﺬه اﻟﺮﺳﺎﻟﺔ دراﺳﺔ ﺗﺤﻠﯿﻠﯿﺔ ﻟﺒﻌﺾ أدوﯾﺔ ﺗﺤﺘﻮي ﻋﻠﻰ ﻣﺠﻤﻮﻋﺔ الامينو ﺳﻮاء ﻣﻨﻔﺮدة أو ﻓﻲ مخاليط. وﻗﺪ ﺗﻢ اﺧﺘﯿﺎر ﺑﻌﺾ اﻟﻤﺮﻛﺒﺎت وھﻲ تيريفلونومايد بالاضافة الي خليط من الدورزولامايد هيدروكلوريد و تيمولول ماليات واﻟﮭﺪف ﻣﻦ ھﺬه اﻟﺮﺳﺎﻟﺔ ھﻮ اﺳﺘﻨﺒﺎط طﺮاﺋﻖ ﺟﺪﯾﺪة ﺗﺘﻤﯿﺰ ﺑﺎﻟﺒﺴﺎطﺔ واﻟﺪﻗﺔ ودرﺟﺔ اﻟﺤﺴﺎﺳﯿﺔ اﻟﻤﻨﺎﺳﺒﺔ ﻟﺘﺤﻠﯿﻞ ھﺬه اﻟﻤﺮﻛﺒﺎت ﻓﻲ وﺟﻮد ﻧﻮاﺗﺞ ﺗﺤﻠﻠﮭﺎ و/أو اﻟﺸﻮاﺋﺐ وﻛﺬﻟﻚ ﻓﻲ وﺟﻮد أدوﯾﺔ أﺧﺮى، وإﻣﻜﺎﻧﯿﺔ ﺗﻄﺒﯿﻖ اﻟﻄﺮاﺋﻖ اﻟﻤﺴﺘﺤﺪﺛﺔ ﻟﺘﺤﻠﯿﻞ اﻷدوﯾﺔ اﻟﻤﺨﺘﺎرة ﻓﻲ ﻣﺴﺘﺤﻀﺮاﺗﮭﺎ اﻟﺼﯿﺪﻟﯿﺔ وﻣﻘﺎرﻧﺘﮭﺎ ﺑﺎﻟﻄﺮاﺋﻖ اﻟﻤﺮﺟﻌﯿﺔ.<br/> ﺗﺤﺘــﻮي ھــﺬه اﻟﺮﺳــﺎﻟﺔ ﻋﻠــﻰ اربعة أﺟــﺰاء ﺗﺘﻀــﻤﻦ اﻟﺘــﺮاث اﻟﻌﻠﻤــﻲ واﻟﺪراﺳــﺔ اﻟﻌﻤﻠﯿــﺔ كما تحتوي علي اثنان و عشرون صورة و ثمانية عشر جدول وسبعون مرجع. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmaceutical Chemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الكيمياء الصيدلية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | RP-HPLC |
| -- | Teriflunomide |
| -- | Stability indicating |
| -- | HPTLC |
| -- | Validation |
| -- | UV-spectrophotometric approaches |
| -- | derivative spectroscopy |
| -- | dual-wavelength ratio spectra |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Elsayed Zaazaa |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nahla Sayed Ismail |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shereen Ahmed Boltia |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Hala Elsayed Zaazaa |
| -- | Nahla Sayed Ismail |
| -- | Shereen Ahmed Boltia |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Analytical Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 09.09.2025 | 92000 | Cai01.08.03.M.Sc.2025.Ma.A | 01010110092000000 | 09.09.2025 | 09.09.2025 | Thesis |