Possible synergistic effect of resveratrol and exercise on testicular functions in metformin-treated type 2 diabetic rats / (Record no. 174815)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05386namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251019112848.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251013s2023 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 612 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 612 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.30.M.Sc.2023.Ay.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Ayat Hussein Mohamed Youssef Omara, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Possible synergistic effect of resveratrol and exercise on testicular functions in metformin-treated type 2 diabetic rats / |
| Statement of responsibility, etc. | by Ayat Hussein Mohamed Youssef Omara ; Supervision Prof. Dr. Effat A. Khowailed, Dr. Nancy Fouad Samir, Dr. Ahmed Fawzy Nofal. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثيرالتآزري المحتمل للريسفيراترول وممارسة الرياضة على وظائف الخصية في الفئران المصابة بداء السكري (النوع الثاني) المعالجة بالميتفورمين |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 156 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 126-156. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Testicular dysfunction is one of the complications of type 2 diabetes mellitus (T2DM) in men, this is illustrated by androgen deficiency, deterioration of sperm quality and the impaired fertility. Hence, trials to restore the testicular functions using pharmacological and non-pharmacological approaches are of a great interest.<br/>Aim of work: The present study was designed to compare the possible therapeutic effects of exercise (EX) versus resveratrol (RES) on steroidogenic and spermatogenic functions in streptozotocin (STZ)-induced T2DM in adult male albino rats receiving metformin (Met) treatment.<br/>Materials and Methods: The study was conducted on 48 rats equally divided into 6 groups (control, T2DM, Met, EX, RES and EX+RES). At the end of the study (8 weeks following T2DM induction), rats were sacrificed, semen was collected as well as blood sample for assessment of fasting glucose, insulin, testosterone, FSH and LH. Testicular tissues were collected for measurement of MDA, TAC and TNFα, gene expression of GDNF, histopathological examination and immunohistochemistry examination for Gfrα1 and c-RET. <br/>Results: STZ-induced T2DM revealed deterioration of rats’ spermatogenic function with decreased GDNF and Gfrα1 and c-RET expression in testicular tissue and also seminiferous tubules losing their normal structure. Increase in MDA and TNFα in testicular tissue with decrease in TAC. As well as disturbed HPG axis. Treatment with EX or RES alleviated the testicular functions, partially restored the histological features and increased GDNF, Gfrα1 and c-RET expression, notably, the combined therapy was better than the mono-therapy. <br/>Conclusion: EX and RES attenuate testicular dysfunctions in STZ-induced T2DM attributed to their antioxidant and anti-inflammatory effects together with overexpression of GDNF. Interestingly combined therapy showed a better improving effect compared to mono-therapy of either EX or RES. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | داء السكري هو متلازمة تمثيل غذائي، يتميز بارتفاع مزمن في سكر الدم ويمثل عبئا عالميا ضخما بسبب انتشاره المتزايد باستمرار، وله آثار تنتشر في جميع أجهزة الجسم ويعد تدهور الوظائف الإنجابية أحد أخطر مضاعفات داء السكري من النوع الثاني.<br/>ولهذا درسنا دور ممارسة التمارين الرياضة مقابل الريسفيراترول كونهما موادا مساعدة للميتفورمين في تحسين تدهور وظائف الخصية في الفئران المصابة بالنوع الثاني من داء السكري. كما قمنا بالتحقيق في الآثار المفيدة المحتملة للعلاج المشترك بممارسة التمارين الرياضية و الريسفيراترول في تنظيم حالة الالتهاب و الإجهاد التأكسدي الناجم عن النوع الثاني من داء السكري، بالإضافة إلى دورهما في التعبير عن عامل التغذية العصبية الدبقي GDNF المعروف بقدرته على تجديد الخلايا الجذعية المنوية.<br/>أجريت الدراسة على 48 من ذكور الفئران البيضاء البالغة بوزن يتراوح بين (180-200 جم). |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Physiology |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الفسيولوجيا |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | T2DM |
| -- | Testicular dysfunction |
| -- | Resveratrol |
| -- | Exercise |
| -- | GDNF |
| -- | Gfrα1 |
| -- | c-RET |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Effat A. Khowailed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nancy Fouad Samir |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Fawzy Nofal |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2023 |
| Supervisory body | Effat A. Khowailed |
| -- | Nancy Fouad Samir |
| -- | Ahmed Fawzy Nofal. |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Physiology (Basic Medical Sciences) |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 13.10.2025 | 92161 | Cai01.11.30.M.Sc.2023.Ay.P | 01010110092161000 | 13.10.2025 | 13.10.2025 | Thesis |