Design, synthesis and biological evaluation of certain 1,1-disubstituted-cycloalkanes / (Record no. 174821)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05197namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251023113824.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251014s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.19 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.05.Ph.D.2025.Mo.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mostafa Abd El-Mohsen Anwar, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and biological evaluation of certain 1,1-disubstituted-cycloalkanes / |
| Statement of responsibility, etc. | by Mostafa Abd El-Mohsen Anwar ; Supervision Prof. Dr. Samir Mohamed El-Moghazy, Prof. Dr. Eman Raafat Mohammed, Prof. Dr. Walaa Hamada Abd-Allah. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتشييد وتقييم الفاعليه البيولوجية لبعض ١,١ثنائي مشتقات السيكلو ألكان |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 192 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 115-129. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Convulsions are sophisticated neurological chronic disorder, which is described by incidence of recurrent, impulsive, cerebral seizure accompanied by sensory motor, psychic as well as autonomic symptoms. Epileptic fits cause the incident of transitory symptoms as a result of extreme synchronous abnormal activity. According to the most recent “World Health Organization (WHO)” statistics, nearly 50 million individuals across the globe suffer from epilepsy. Different medical groups have reached consensus on a number of antiepileptic drugs (AEDs) that can effectively treat or prevent seizures. However, anywhere from 25 percent to 40 percent of patients still deal with uncontrolled seizures and other, often severe, side effects. The treatment of epilepsy requires the continuous administration of AEDs to abolish or reduce the incidence of seizures frequency, as well as the administration of additional pharmaceuticals to avoid the adverse pharmacological effects that may come from unfavorable drug interactions. More antiepileptic drugs have been announced to the market in the last decade, with some indications of advances in the treatment of epilepsy. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | الصرع هو خلل في نقل الإشارات الكهربائية في داخل الدماغ، وبالرغم من أن الاعتقاد الشائع هو أن مرض الصرع يُسبب دائمًا نوبة من الحركة اللاإرادية وفقدان الوعي إلا أن مرض الصرع في الحقيقة يظهر بصور متنوعة جدًا.<br/>إن الحالات التي تظهر فيها العلامات المعروفة بالنوبة الصرعيّة تكون على الأغلب ضمنية تثير أحاسيس غريبة وحساسية زائدة وتصرفات شاذة، بعض المصابين بمرض الصرع يحدقون في الفضاء لمدة ما عندما تصيبهم النوبة بينما يعاني آخرون من اختلاجات وتشنجات حادة.<br/>أشخاص كثيرون، مثل: الأطفال الذين يعانون من الحمّى قد يعانون من نوبة صرعية لمرة واحدة، أما إذا تكررت الحالة وأصيب شخص ما بنوبتين صرعيّتين فإن احتمال التعرض لنوبة أخرى ثالثة يرتفع بصورة جدية جدًا، ومن الجدير بذكره أنه يجب الإصابة بنوبيتين على الأقل من أجل تشخيص مرض الصرع.<br/>يظهر مرض الصرع بشكل عام في مرحلة الطفولة أو لدى البالغين و كذلك فوق سن 65 سنة، ومع هذا قد يظهر مرض الصرع في أية مرحلة عمرية.<br/>علاج الصرع الصحيح والمناسب يمكن أن يجنّب المريض النوبات الصرعيّة أو أن يقلل على الأقل وتيرة حدوثها ودرجة حدّتها، كما أن كثيرين من الأطفال والأولاد المصابين بالصرع يتعافون ويشفون منه في مرحلة البلوغ.<br/>لهذا تتناول هذه الدراسة تشييد بعض الجزيئات المشتقة من ١,١ سيكلوألكان ثنائي الأستبدال وذلك بهدف تقييم خصائصها المضادة للصرع. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmaceutical Chemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الكيمياء الصيدلية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anti-epileptics |
| -- | geminally disubstituted cyclohexane |
| -- | GABA |
| -- | GABA-AT |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samir Mohamed El-Moghazy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Raafat Mohammed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walaa Hamada Abd-Allah |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Samir Mohamed El-Moghazy |
| -- | Eman Raafat Mohammed |
| -- | Walaa Hamada Abd-Allah |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmaceutical Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 14.10.2025 | 92164 | Cai01.08.05.Ph.D.2025.Mo.D | 01010110092164000 | 14.10.2025 | 14.10.2025 | Thesis |